Evidence map›Paper›PMID 28962419›Full record

ArticleToxicology reports2015

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells.

Puttappa R Dodmane, Lora L Arnold, Karen L Pennington, Rakesh K Singh, Ana Paula Ferragut Cardoso, Samuel M Cohen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Puttappa R DodmaneDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
Lora L ArnoldDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
Karen L PenningtonDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
Rakesh K SinghDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
Ana Paula Ferragut CardosoDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
Samuel M CohenDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.
University of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic exposure to high levels of inorganic arsenic (iAs) has been associated with cancerous and non-cancerous health effects, including cardiovascular effects. However, the mechanism for a presumed toxic effect of arsenic on vascular tissue is not clear. Our working hypothesis is that inorganic trivalent arsenic and its methylated metabolites react with cysteine-containing cellular proteins and alter their function leading to adverse events such as cytotoxicity or proliferation. In this study, human microvascular endothelial cells (HMEC1) and mouse microvascular endothelial cells (MFP-MVEC) were exposed to arsenite (iAs

Indexed as

ArsenicCardiovascularCytotoxicityMitogenesis

Identifiers

PMID28962419
PMCPMC5598208
OpenAlexW220933182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.