Evidence map›Paper›PMID 28962398›Full record

ArticleToxicology reports2015

Mitochondrial toxicity of triclosan on mammalian cells.

Charmaine Ajao, Maria A Andersson, Vera V Teplova, Szabolcs Nagy, Carl G Gahmberg, Leif C Andersson, Maria Hautaniemi, Balazs Kakasi, Merja Roivainen, Mirja Salkinoja-Salonen

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 115 citations in OpenAlex.

  1. Article
  2. Treatment ofAntimicrobial agents and chemotherapy · 2025
    Article
  3. Article
  4. Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology.International journal of environmental research and public health · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Mining Fatty Acid Biosynthesis for New Antimicrobials.Annual review of microbiology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Triclosan disrupts immune cell function by depressing CaToxicology and applied pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Charmaine AjaoDepartment of Food and Environmental Sciences, Haartman Institute, University of Helsinki, POB 56, FI-00014, Finland.
Maria A AnderssonDepartment of Food and Environmental Sciences, Haartman Institute, University of Helsinki, POB 56, FI-00014, Finland.
Vera V TeplovaInstitute of Theoretical and Experimental Biophysics, RAS, Puschino, Moscow Region, Russia.
Szabolcs NagyDepartment of Animal Science and Animal Husbandry, University of Pannonia, Georgikon Faculty, Deak F. u.,16, H8360 Keszthely, Hungary.
Carl G GahmbergDept. of Bio- and Environmental Sciences, Haartman Institute, University of Helsinki, FI-00014, Finland.
Leif C AnderssonDept. of Pathology, Haartman Institute, University of Helsinki, FI-00014, Finland.
Maria HautaniemiFinnish Food Safety Authority (EVIRA), Research and Laboratory Department, Veterinary Virology Research Unit, Mustialankatu 3, FI 00790 Helsinki, Finland.
Balazs KakasiInstitute of Environmental Sciences, University of Pannonia, Egyetem u. 10, H-8200 Veszprem, Hungary.
Merja RoivainenNational Institute for Health and Welfare, Department of Virology, Mannerheimintie 166, 00300 Helsinki, Finland.
Mirja Salkinoja-SalonenDepartment of Food and Environmental Sciences, Haartman Institute, University of Helsinki, POB 56, FI-00014, Finland.
University of Helsinki · FIUniversity of Pannonia · HUFinnish Food Authority · FIFinnish Institute for Health and Welfare · FIInstitute of Theoretical and Experimental Biophysics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effects of triclosan (5-chloro-2'-(2,4-dichlorophenoxy)phenol) on mammalian cells were investigated using human peripheral blood mono nuclear cells (PBMC), keratinocytes (HaCaT), porcine spermatozoa and kidney tubular epithelial cells (PK-15), murine pancreatic islets (MIN-6) and neuroblastoma cells (MNA) as targets. We show that triclosan (1-10 μg ml

Indexed as

AcidosisBCF, bioconcentration factorEC50, concentration that diminishes the respective vitality parameter by ≥50%Electric transmembrane potentialGlycolysisHaCaT, a spontaneously immortalized (non-neoplastic) keratinocyte cell lineJC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanine iodideMIC, minimal inhibitory concentrationMIN-6, a murine pancreatic beta cell lineMNA, a murine neuroblastoma cellsOxidative phosphorylationPBMC, monocyte-enriched peripheral blood mononuclear cellsPI, propidium iodidePK-15, a porcine kidney tubular epithelial cell linePN, pyridine nucleotidesRLM, rat liver mitochondriaSperm motilityTPP+, tetraphenylphosphoniumUncouplerΔΨ, electric transmembrane potentialΔΨm, membrane potential of the mitochondrial membraneΔΨp, membrane potential of the plasma membrane

Identifiers

PMID28962398
PMCPMC5598359
OpenAlexW2108397814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.