Evidence map›Paper›PMID 28962324›Full record

ArticleToxicology reports2014

Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway.

Verena Christen, Magdalena Camenzind, Karl Fent

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  13. Acute Exposure to SiONeurotoxicity research · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Verena ChristenUniversity of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
Magdalena CamenzindUniversity of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
Karl FentSwiss Federal Institute of Technology Zürich (ETH Zürich), Department of Environmental Systems Science, CH-8092 Zürich, Switzerland.
FHNW University of Applied Sciences and Arts · CHETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Application of silica nanoparticles (SiO

Indexed as

ATF-4, Activating transcription factor 4ATF-6, activating transcription factor 6BiP, binding immunoglobulin proteinCHOP, CCAAT/enhancer binding protein-homologous proteinCREB, cAMP response element-binding proteineIF2α, eukaryotic initiation factor 2αHuh7, human hepatoma cellsHuman hepatoma cellsIFN α, interferon αIFN β, interferon βIP-10, interferon gamma-induced protein 10IRE-1, inositol-requiring protein 1IRF-9, interferon regulatory factor 9ISG-15, interferon-induced 17 kDa proteinISGs, interferon stiulated genesMAPK, mitogen-activated protein kinase signaling pathwayNFκB, nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cellsNoxa, phorbol-12-myristate-13-acetate-induced protein 1p53, TP53-tumorsuppressor-genePERK, protein kinase like ER kinasePP2A, protein phosphatase 2aProinflammatory response ;Iinterferon-stimulated genesSiO2-NPs, silica nanoparticlesSTAT1, signal transducer and activator of transcription 1TNFα, tumor necrosis factor αTumor necrosis factor alphaUPR, unfolded protein responseXBP-1, X-box binding protein 1

Identifiers

PMID28962324
PMCPMC5598250
OpenAlexW2059425694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.