Evidence map›Paper›PMID 28962307›Full record

ArticleToxicology reports2014

Canola and hydrogenated soybean oils accelerate ectopic bone formation induced by implantation of bone morphogenetic protein in mice.

Yoko Hashimoto, Mayumi Mori, Shuichiro Kobayashi, Akira Hanya, Shin-Ichi Watanabe, Naoki Ohara, Toshihide Noguchi, Tatsushi Kawai, Harumi Okuyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yoko HashimotoDepartment of Biochemistry, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Mayumi MoriDepartment of Pharmacology, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan.
Shuichiro KobayashiDepartment of Periodontology, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Akira HanyaFood Research Center, Aichi Center for Industry and Science Technology, 2-1-1 Shinpukuji-cho, Nishi-ku, Nagoya 451-0083, Japan.
Shin-Ichi WatanabeKinjo Gakuin University College of Pharmacy, Omori, Moriyama-ku, Nagoya 463-8521, Japan.
Naoki OharaKinjo Gakuin University College of Pharmacy, Omori, Moriyama-ku, Nagoya 463-8521, Japan.
Toshihide NoguchiDepartment of Periodontology, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Tatsushi KawaiDepartment of Dental Material Science, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Harumi OkuyamaKinjo Gakuin University College of Pharmacy, Omori, Moriyama-ku, Nagoya 463-8521, Japan.
Aichi Gakuin University · JPKinjo Gakuin University · JPNagoya City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canola oil (Can) and hydrogenated soybean oil (H2-Soy) are commonly used edible oils. However, in contrast to soybean oil (Soy), they shorten the survival of stroke-prone spontaneously hypertensive (SHRSP) rats. It has been proposed that the adverse effects of these oils on the kidney and testis are caused at least in part by dihydro-vitamin K (VK) 1 in H2-Soy and unidentified component(s) in Can. Increased intake of dihydro-VK1 is associated with decreased tissue VK2 levels and bone mineral density in rats and humans, respectively. The aim of the present study was to determine the effects of these oils on bone morphogenetic protein (BMP)-induced ectopic bone formation, which is promoted by VK2 deficiency, in relation to the role of VK in the γ-carboxylation of osteocalcin and matrix Gla protein. A crude extract of BMPs was implanted into a gap in the fascia of the femoral muscle in 5-week-old mice maintained on a Soy, Can, or H2-Soy diet. Newly formed bone volume, assessed by three-dimensional X-ray micro-computed tomography and three-dimensional reconstruction imaging for bone, was 4-fold greater in the Can and H2-Soy groups than in the Soy group. The plasma carboxylated osteocalcin (Gla-OC) and total OC (Gla-OC plus undercarboxylated osteocalcin [Glu-OC]) levels were significantly lower in the Can group than in the Soy group (

Indexed as

4056): Vitamin K3 (PubChem CID: 4055)BMP, bone morphogenetic proteinBone morphogenetic proteinCan, canola oilCanola oilcMGP, carboxylated matrix Gla proteinDihydro-vitamin K1 (PubChem CID: 152059)dihydro-VK1, 2′, 3′-dihydro-vitamin K1Ectopic calcificationG6PDH, glucose-6-phosphate dehydrogenaseGla, carboxyglutamic acidGla-OC, carboxylated osteocalcinGlu-OC, undercarboxylated osteocalcinH2-Soy, hydrogenated soybean oilHydrogenated soybean oilMatrix Gla proteinmCT, micro-computed tomographyOsteocalcinSHRSP rat, stroke-prone spontaneously hypertensive ratSoy, soybean oilTRI/3D-BON, three-dimensional reconstruction imaging for boneucMGP, undercarboxylated MGPVitamin KVitamin K1 hydroquinone (PubChem CID: 5280585)Vitamin K1 (PubChem CID: 52384607)Vitamin K2 (PubChem CIDVK, vitamin K

Identifiers

PMID28962307
PMCPMC5598561
OpenAlexW1994122714

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.