ArticleToxicology reports2014
The combined effects of physicochemical properties of size-fractionated ambient particulate matter on
Article in Toxicology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 98 citations in OpenAlex.
- Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill.Particle and fibre toxicology · 2018Trial
- Molecular Characterization of the Air Microbiome and Associated Toxicological Hazards in a Zoological Garden.International journal of molecular sciences · 2026Article
- Characterization of the Chemical Composition, Cytotoxicity, and Metabolomic Effects of PMToxics · 2025Article
- Cytotoxicity and Epithelial Barrier Toxicity of Fine Particles from Residential Biomass Pellet Burning.Environmental science & technology · 2024Article
- Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure.Particle and fibre toxicology · 2024Article
- In vitro toxicity assessment of bioavailable iron in coal varieties of Central India.PloS one · 2024Article
- Exposure to urban nanoparticles at low PM[Formula: see text] concentrations as a source of oxidative stress and inflammation.Scientific reports · 2023Article
- Assessing the cytotoxicity of aerosolized carbon black and benzo[a]pyrene with controlled physical and chemical properties on human lung epithelial cells.Scientific reports · 2023Article
- Toxicological Effects of Secondary Air Pollutants.Chemical research in Chinese universities · 2023Review
- RNA-Seq Analysis of UPM-Exposed Epithelium Co-Cultivated with Macrophages and Dendritic Cells in Obstructive Lung Diseases.International journal of molecular sciences · 2022Article
- Potential cytotoxicity of trace elements and polycyclic aromatic hydrocarbons bounded to particulate matter: a review on in vitro studies on human lung epithelial cells.Environmental science and pollution research international · 2021Review
- PARP-1 overexpression does not protect HaCaT cells from DNA damage induced by SiOToxicology research · 2021Article
- Development of a system for the detection of the inflammatory response induced by airborne fine particulate matter in rat tracheal epithelial cells.Toxicology reports · 2020Article
- Moderate-intensity physical activity reduces systemic inflammation and maintains cardiorespiratory function following chronic particulate matterToxicology reports · 2020Article
- Development of a system for the detection of the inflammatory response induced by airborne fine particulate matter in rat tracheal epithelial cells.Toxicology reports · 2020Article
- Morin Protects Human Respiratory Cells from PMInternational journal of environmental research and public health · 2019Article
- Concentration, sources and human health risk of heavy metals and polycyclic aromatic hydrocarbons bound PMEnvironmental geochemistry and health · 2019Article
- Toxicity potential of particles caused by particle-bound polycyclic aromatic hydrocarbons (PPAHs) at two roadside locations and relationship with traffic.Environmental science and pollution research international · 2018Article
- REDUCTION OF PM2.5 TOXICITY ON HUMAN ALVEOLAR EPITHELIAL CELLS A549 BY TEA POLYPHENOLS.Journal of food biochemistry · 2018Article
- Dust at Various Workplaces-Microbiological and Toxicological Threats.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological and toxicological studies have suggested that the health effects associated with exposure to particulate matter (PM) are related to the different physicochemical properties of PM. These effects occur through the initiation of differential cellular responses including: the induction of antioxidant defenses, proinflammatory responses, and ultimately cell death. The main objective of this study was to investigate the effects of size-fractionated ambient PM on epithelial cells in relation to their physicochemical properties. Concentrated ambient PM was collected on filters for three size fractions: coarse (aerodynamic diameter [AD] 2.5-10 μm), fine (0.15-2.5 μm), and quasi-ultrafine (<0.2 μm), near a busy street in Toronto, Ontario, Canada. Filters were extracted and analyzed for chemical composition and redox activity. Chemical analyses showed that the coarse, fine, and quasi-ultrafine particles were comprised primarily of metals, water-soluble species, and organic compounds, respectively. The highest redox activity was observed for fine PM. After exposure of A549 cells to PM (10-100 μg/ml) for 4 h, activation of antioxidant, proinflammatory and cytotoxic responses were assessed by determining the expression of heme oxygenase (HMOX-1, mRNA), interleukin-8 (IL-8, mRNA), and metabolic activity of the cells, respectively. All three size fractions induced mass-dependent antioxidant, proinflammatory, and cytotoxic responses to different degrees. Quasi-ultrafine PM caused significant induction of HMOX-1 at the lowest exposure dose. Correlation analyses with chemical components suggested that the biological responses correlated mainly with transition metals and organic compounds for coarse and fine PM and with organic compounds for quasi-ultrafine PM. Overall, the observed biological responses appeared to be related to the combined effects of size and chemical composition and thus both of these physicochemical properties should be considered when explaining PM toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.