ArticleExperimental and therapeutic medicine2017
Circulating and peritoneal fluid interleukin-6 levels and gene expression in pelvic endometriosis.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Establishment of pathology-validated immortalized patient-derived ovarian endometriosis epithelial cell line.Biomedical reports · 2026Article
- Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines.F&S reports · 2026Article
- An Overview of Endometriosis and Potential Pharmacogenetic Targets.Pharmaceutical research · 2026Review
- Review
- Association of maternal endometriosis with autism spectrum disorder in offspring: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Is Osteopontin a Reliable Biomarker for Endometriosis?International journal of molecular sciences · 2024Article
- Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses.Heliyon · 2024Review
- Neurotrophins and Their Receptors, Novel Therapeutic Targets for Pelvic Pain in Endometriosis, Are Coordinately Regulated by IL-1β via the JNK Signaling Pathway.The American journal of pathology · 2023Article
- Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis.International journal of molecular sciences · 2023Article
- Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis.Frontiers in immunology · 2023Article
- Inflammatory Mediators and Pain in Endometriosis: A Systematic Review.Biomedicines · 2021Review
- Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells.Journal of cellular and molecular medicine · 2021Article
- Integrated analysis of mRNA and protein expression profiling in tubal endometriosis.Reproduction (Cambridge, England) · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current data are inconsistent regarding the association between interleukin-6 (IL-6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL-6 levels in serum and peritoneal fluid (PF), as well as IL-6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case-control study. IL-6 levels in PF and serum were determined using a human enzyme-linked immunosorbent assay and IL-6 gene expression was evaluated using reverse transcription-quantitative polymerase chain reaction. It was observed that IL-6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL-6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL-6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL-6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL-6 and the presence and severity of pelvic endometriosis. The source of this higher IL-6 seems not to be specifically related to regional AT.
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