ArticleMolecular biology and evolution2017
Natural Selection Drives Rapid Functional Evolution of Young Drosophila Duplicate Genes.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Adaptive deletion of functional duplicate genes in Drosophila.Journal of evolutionary biology · 2026Article
- Adaptive deletion of functional duplicate genes inbioRxiv : the preprint server for biology · 2025Article
- Evolutionary Changes ofEcology and evolution · 2025Article
- A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH).G3 (Bethesda, Md.) · 2024Article
- Predicting evolutionary targets and parameters of gene deletion from expression data.Bioinformatics advances · 2024Article
- Somatic genome architecture and molecular evolution are decoupled in "young" linage-specific gene families in ciliates.PloS one · 2024Article
- Evolution of the Growth Hormone Gene Duplication in Passerine Birds.Genome biology and evolution · 2023Article
- Parallel evolution of amphioxus and vertebrate small-scale gene duplications.Genome biology · 2022Article
- Three problems in the genetics of speciation by selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional Divergence of the bag-of-marbles Gene in the Drosophila melanogaster Species Group.Molecular biology and evolution · 2022Article
- Evidence from Drosophila Supports Higher Duplicability of Faster Evolving Genes.Genome biology and evolution · 2022Article
- Multilevel evolution shapes the function of NB-LRR encoding genes in plant innate immunity.Frontiers in plant science · 2022Review
- Evidence of Adaptive Evolution inViruses · 2021Article
- Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development.PLoS genetics · 2021Article
- Plant NLR diversity: the known unknowns of pan-NLRomes.The Plant cell · 2021Review
- Learning Retention Mechanisms and Evolutionary Parameters of Duplicate Genes from Their Expression Data.Molecular biology and evolution · 2021Article
- Population-Specific Genetic and Expression Differentiation in Europeans.Genome biology and evolution · 2020Article
- A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function.Molecular biology and evolution · 2020Article
- Article
- Haploid selection drives new gene male germline expression.Genome research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication is thought to play a major role in phenotypic evolution. Yet the forces involved in the functional divergence of young duplicate genes remain unclear. Here, we use population-genetic inference to elucidate the role of natural selection in the functional evolution of young duplicate genes in Drosophila melanogaster. We find that negative selection acts on young duplicates with ancestral functions, and positive selection on those with novel functions, suggesting that natural selection may determine whether and how young duplicate genes are retained. Moreover, evidence of natural selection is strongest in protein-coding regions and 3' UTRs of young duplicates, indicating that selection may primarily target encoded proteins and regulatory sequences specific to 3' UTRs. Further analysis reveals that natural selection acts immediately after duplication and weakens over time, possibly explaining the observed bias toward the acquisition of new functions by young, rather than old, duplicate gene copies. Last, we find an enrichment of testis-related functions in young duplicates that underwent recent positive selection, but not in young duplicates that did not undergo recent positive selection, or in old duplicates that either did or did not undergo recent positive selection. Thus, our findings reveal that natural selection is a key player in the functional evolution of young duplicate genes, acts rapidly and in a region-specific manner, and may underlie the origin of novel testis-specific phenotypes in Drosophila.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.