Evidence map›Paper›PMID 28961702›Full record

ArticleBioinformatics (Oxford, England)2018

MWASTools: an R/bioconductor package for metabolome-wide association studies.

Andrea Rodriguez-Martinez, Joram M Posma, Rafael Ayala, Ana L Neves, Maryam Anwar, Enrico Petretto, Costanza Emanueli, Dominique Gauguier, Jeremy K Nicholson, Marc-Emmanuel Dumas

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. NMR-Based Metabolomics in Cancer Research.Advances in experimental medicine and biology · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea Rodriguez-MartinezDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Joram M PosmaDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Rafael AyalaDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Ana L NevesDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Maryam AnwarDivision of Myocardial Function, National Heart and Lung Institute, Imperial College London, UK.
Enrico PetrettoDuke-NUS Medical School, Singapore.
Costanza EmanueliDivision of Myocardial Function, National Heart and Lung Institute, Imperial College London, UK.
Dominique GauguierDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Jeremy K NicholsonDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.
Marc-Emmanuel DumasDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, UK.

Funding

British Heart Foundation RG/15/5/31446Medical Research Council MC_U120097112
6 · The paper itself

Abstract

Summary: MWASTools is an R package designed to provide an integrated pipeline to analyse metabonomic data in large-scale epidemiological studies. Key functionalities of our package include: quality control analysis; metabolome-wide association analysis using various models (partial correlations, generalized linear models); visualization of statistical outcomes; metabolite assignment using statistical total correlation spectroscopy (STOCSY); and biological interpretation of metabolome-wide association studies results. Availability and implementation: The MWASTools R package is implemented in R (version  > =3.4) and is available from Bioconductor: https://bioconductor.org/packages/MWASTools/. Contact: m.dumas@imperial.ac.uk. Supplementary information: Supplementary data are available at Bioinformatics online.

Indexed as

MetabolomeSoftwareGenetic Association StudiesHumansMetabolomicsModels, BiologicalQuality Control

Identifiers

PMID28961702
PMCPMC6049002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.