ArticleCortex; a journal devoted to the study of the nervous system and behavior2017
Linking left hemispheric tissue preservation to fMRI language task activation in chronic stroke patients.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- BDNF genotype and tDCS interaction in aphasia treatment.Brain stimulationTrial
- Dynamic functional reorganization in post-stroke aphasia: a state-of-the-art fMRI review from disease evolution to intervention.Frontiers in neuroscience · 2026Review
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.medRxiv : the preprint server for health sciences · 2025Article
- Patterns of Visual Task-based Functional MRI Activation in Chronic Posterior Cerebral Artery Stroke Patients.Clinical neuroradiology · 2023Article
- Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping.Brain : a journal of neurology · 2022Article
- An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson's Disease in Early-Stage.Frontiers in aging neuroscience · 2021Article
- Lesion Quantification Toolkit: A MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions.NeuroImage. Clinical · 2021Article
- Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Naming errors and dysfunctional tissue metrics predict language recovery after acute left hemisphere stroke.Neuropsychologia · 2020Article
- Across-session consistency of context-driven language processing: A magnetoencephalography study.The European journal of neuroscience · 2020Article
- Damage to the shortest structural paths between brain regions is associated with disruptions of resting-state functional connectivity after stroke.NeuroImage · 2020Article
- A Taxonomy of Brain-Behavior Relationships After Stroke.Journal of speech, language, and hearing research : JSLHR · 2019Review
- Language Mapping in Aphasia.Journal of speech, language, and hearing research : JSLHR · 2019Review
- Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: Spatial neglect and attention.NeuroImage · 2019Article
- Structural Disconnections Explain Brain Network Dysfunction after Stroke.Cell reports · 2019Article
- Multivariate Approaches to Understanding Aphasia and its Neural Substrates.Current neurology and neuroscience reports · 2019Review
- A lesion and connectivity-based hierarchical model of chronic aphasia recovery dissociates patients and healthy controls.NeuroImage. Clinical · 2019Article
- Perilesional and homotopic area activation during proverb comprehension after stroke.Brain and behavior · 2019Article
- Facilitation of Auditory Comprehension After Theta Burst Stimulation of Wernicke's Area in Stroke Patients: A Pilot Study.Frontiers in neurology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The preservation of near-typical function in distributed brain networks is associated with less severe deficits in chronic stroke patients. However, it remains unclear how task-evoked responses in networks that support complex cognitive functions such as semantic processing relate to the post-stroke brain anatomy. Here, we used recently developed methods for the analysis of multimodal MRI data to investigate the relationship between regional tissue concentration and functional MRI activation evoked during auditory semantic decisions in a sample of 43 chronic left hemispheric stroke patients and 43 age, handedness, and sex-matched controls. Our analyses revealed that closer-to-normal levels of tissue concentration in left temporo-parietal cortex and the underlying white matter correlated with the level of task-evoked activation in distributed regions associated with the semantic network. This association was not attributable to the effects of left hemispheric lesion or brain volumes, and similar results were obtained when using explicit lesion data. Left temporo-parietal tissue concentration and the associated task-evoked activations predicted patient performance on the in-scanner task, and also predicted patient performance on out-of-scanner naming and verbal fluency tasks. Exploratory analyses using the average HCP-842 tractography dataset revealed the presence of fronto-temporal, fronto-parietal, and temporo-parietal semantic network connections in the locations where tissue concentration was found to correlate with task-evoked activation in the semantic network. In summary, our results link the preservation of left posterior temporo-parietal structures with the preservation of task-evoked semantic network function in chronic left hemispheric stroke patients. Speculatively, this relationship may reflect the status of posterior temporo-parietal areas as cortical and white matter convergence zones that support coordinated processing in the distributed semantic network. Damage to these regions may contribute to atypical task-evoked responses during semantic processing in chronic stroke patients.
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