Evidence map›Paper›PMID 28961166›Full record

ArticleInternational journal of molecular sciences2017

High Levels of Circulating Type II Collagen Degradation Marker (CTx-II) Are Associated with Specific VDR Polymorphisms in Patients with Adult Vertebral Osteochondrosis.

Sabina Cauci, Marco Viganò, Laura de Girolamo, Paola De Luca, Carlotta Perucca Orfei, Giuseppe Banfi, Giovanni Lombardi, Marco Brayda-Bruno, Alessandra Colombini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Observational
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sabina CauciDepartment of Medicine, University of Udine, 33100 Udine, Italy. sabina.cauci@uniud.it.
Marco ViganòOrthopaedic Biotechnology Lab, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy. marco.vigano@grupposandonato.it.ORCID 0000-0002-6463-6564
Laura de GirolamoOrthopaedic Biotechnology Lab, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy. laura.degirolamo@grupposandonato.it.
Paola De LucaOrthopaedic Biotechnology Lab, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy. deluca.paola@grupposandonato.it.
Carlotta Perucca OrfeiOrthopaedic Biotechnology Lab, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy. carlotta.perucca@grupposandonato.it.
Giuseppe BanfiVita-Salute San Raffaele University, 20132 Milan, Italy. banfi.giuseppe@fondazionesanraffaele.it.
Giovanni LombardiLaboratory of Experimental Biochemistry & Molecular Biology, IRCCS Galeazzi Orthopaedic Institute, 20161 Milan, Italy. giovanni.lombardi@grupposandonato.it.
Marco Brayda-BrunoDepartment of Orthopedics and Traumatology, Spine Surgery III-Scoliosis Unit, IRCCS Galeazzi Orthopaedic Institute, 20161 Milan, Italy. marco.brayda@spinecaregroup.it.
Alessandra ColombiniOrthopaedic Biotechnology Lab, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy. alessandra.colombini@grupposandonato.it.ORCID 0000-0002-1800-3424
Istituto Ortopedico Galeazzi · ITUniversity of Udine · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both vitamin D and collagen have roles in osteocartilaginous homeostasis. We evaluated the association between the circulating 25-hydroxyvitamin D (25(OH)D) type I and II collagen degradation products (CTx-I, and CTx-II), and four vitamin D receptor gene (

Indexed as

Polymorphism, GeneticAdultCollagen Type IIFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansItalyMaleMiddle AgedPeptide FragmentsProteolysisReceptors, CalcitriolSpinal OsteochondrosisYoung AdultCollagen Type IIC-terminal cross-linking telopeptide of type II collagen, humanPeptide FragmentsReceptors, CalcitriolVDR protein, humanadult vertebral osteochondrosisItalian malestype II collagenVDR polymorphisms

Identifiers

PMID28961166
PMCPMC5666755
OpenAlexW2758755058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.