Evidence map›Paper›PMID 28961025›Full record

ReviewAnnual review of genetics2017

Generation and Evolution of Neural Cell Types and Circuits: Insights from the Drosophila Visual System.

Michael Perry, Nikos Konstantinides, Filipe Pinto-Teixeira, Claude Desplan

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. A conserved logic for the development of cortical layering in tetrapods.bioRxiv : the preprint server for biology · 2025
    Article
  2. Review
  3. A Closer Look at Histamine inInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Sphingolipids in neurodegenerative diseases.Frontiers in neuroscience · 2023
    Review
  6. Autocrine/Paracrine Slit-Robo Signaling Controls Optic Lobe Development inFrontiers in cell and developmental biology · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Neuro-evo-devo in the single cell sequencing era.Current opinion in systems biology · 2018
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael PerryDepartment of Biology, New York University, New York, NY 10003, USA; email: cd38@nyu.edu.
Nikos KonstantinidesDepartment of Biology, New York University, New York, NY 10003, USA; email: cd38@nyu.edu.
Filipe Pinto-TeixeiraDepartment of Biology, New York University, New York, NY 10003, USA; email: cd38@nyu.edu.
Claude DesplanDepartment of Biology, New York University, New York, NY 10003, USA; email: cd38@nyu.edu.

Funding

Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Bridging the gap between transcriptional activation and cell fate specification in the Drosophila visual systemK99EY027016 · NEI · NEW YORK UNIVERSITY · PI PERRY, MICHAEL WILLIAM · 2016 to 2017
$272k
NEI NIH HHS K99 EY027016NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY013012
6 · The paper itself

Abstract

The Drosophila visual system has become a premier model for probing how neural diversity is generated during development. Recent work has provided deeper insight into the elaborate mechanisms that control the range of types and numbers of neurons produced, which neurons survive, and how they interact. These processes drive visual function and influence behavioral preferences. Other studies are beginning to provide insight into how neuronal diversity evolved in insects by adding new cell types and modifying neural circuits. Some of the most powerful comparisons have been those made to the Drosophila visual system, where a deeper understanding of molecular mechanisms allows for the generation of hypotheses about the evolution of neural anatomy and function. The evolution of new neural types contributes additional complexity to the brain and poses intriguing questions about how new neurons interact with existing circuitry. We explore how such individual changes in a variety of species might play a role over evolutionary timescales. Lessons learned from the fly visual system apply to other neural systems, including the fly central brain, where decisions are made and memories are stored.

Indexed as

Biological EvolutionAnimalsBrainDrosophila melanogasterDrosophila ProteinsEye ProteinsGene Expression Regulation, DevelopmentalImaginal DiscsLarvaNerve NetNeuropilOrganogenesisPhotoreceptor Cells, InvertebratePhylogenyRetinaVision, BinocularDrosophila ProteinsEye Proteinscell fatedevelopmentevolutionneural diversityneuropil evolutiontemporal series

Identifiers

PMID28961025
PMCPMC5849253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.