Evidence map›Paper›PMID 28960967›Full record

ArticleBiomacromolecules2017

Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types.

Dominic W Malcolm, Margaret A T Freeberg, Yuchen Wang, Kenneth R Sims, Hani A Awad, Danielle S W Benoit

Abstract read
In one paragraph

Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery.Journal of controlled release : official journal of the Controlled Release Society · 2018
    Article
  9. Review
  10. Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2018
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dominic W Malcolm
Margaret A T Freeberg
Yuchen Wang
Kenneth R SimsTranslational Biomedical Science, University of Rochester School of Medicine and Dentistry , Rochester, New York, United States.
Hani A AwadDepartment of Orthopedics, University of Rochester Medical Center , Rochester, New York, United States.
Danielle S W BenoitDepartment of Orthopedics, University of Rochester Medical Center , Rochester, New York, United States.ORCID http://orcid.org/0000-0001-7137-8164

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
Engineering scarless repair of flexor tendon injuriesR01AR056696 · NIAMS · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A, BENOIT, DANIELLE S. · 2009 to 2019
$3.6M
Training in Orthopaedic Researchhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=8841318&folderId=90T32AR053459 · NIAMS · UNIVERSITY OF ROCHESTER · PI ZUSCIK, MICHAEL J · 2006 to 2017
$3.4M
Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutansR01DE018023 · NIDCR · UNIVERSITY OF ROCHESTER · PI KOO, HYUN · 2008 to 2019
$3.4M
Engineered pH-Responsive Nanoparticle Drug Delivery to Inhibit Oral Biofilm FormationF31DE026944 · NIDCR · UNIVERSITY OF ROCHESTER · PI SIMS, KENNETH R · 2017 to 2019
$124k
NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056696NIAMS NIH HHS R01 AR064200NIAMS NIH HHS T32 AR053459NIDCR NIH HHS F31 DE026944NIDCR NIH HHS R01 DE018023
6 · The paper itself

Abstract

pH-responsive diblock copolymers provide tailorable nanoparticle (NP) architecture and chemistry critical for siRNA delivery. Here, diblock polymers varying in first (corona) and second (core) block molecular weight (M

Indexed as

Gene Transfer TechniquesAnimalsGene SilencingHeLa CellsHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMesenchymal Stem Cell TransplantationMiceMuscle, SkeletalNanoparticlesPolyethylene GlycolsPolymersRNA, Small InterferingPolyethylene GlycolsPolymersRNA, Small Interfering

Identifiers

PMID28960967
PMCPMC5736382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.