Evidence map›Paper›PMID 28960868›Full record

ArticleChemMedChem2017

Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.

David Xu, Khuchtumur Bum-Erdene, Yubing Si, Donghui Zhou, Mona K Ghozayel, Samy O Meroueh

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Unconventional Secondary Structure Mimics: Ladder-Rungs.Angewandte Chemie (International ed. in English) · 2020
    Article
  5. Evolution and Medical Significance of LU Domain-Containing Proteins.International journal of molecular sciences · 2019
    Review
  6. Article
  7. Article
  8. Therapeutic potential of targeting the Eph/ephrin signaling complex.The international journal of biochemistry & cell biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David XuCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Khuchtumur Bum-ErdeneDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 4023, Indianapolis, IN, 46202, USA.
Yubing SiCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Donghui ZhouDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 4023, Indianapolis, IN, 46202, USA.
Mona K GhozayelDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 4023, Indianapolis, IN, 46202, USA.
Samy O MerouehDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 4023, Indianapolis, IN, 46202, USA.ORCID 0000-0002-3948-7499
Indiana University School of Medicine

Funding

Small-Molecule Antagonists of Ral GTPases in CancerR01CA197928 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI MEROUEH, SAMY · 2016 to 2020
$2.9M
NCI NIH HHS R01 CA197928
6 · The paper itself

Abstract

Tight protein-protein interactions (K

Indexed as

Binding SitesEnzyme-Linked Immunosorbent AssayHigh-Throughput Screening AssaysHumansInhibitory Concentration 50KineticsMolecular Docking SimulationProtein Interaction Domains and MotifsProtein Structure, TertiaryReceptors, Urokinase Plasminogen ActivatorSmall Molecule LibrariesStructure-Activity RelationshipThermodynamicsUrokinase-Type Plasminogen ActivatorReceptors, Urokinase Plasminogen ActivatorSmall Molecule LibrariesUrokinase-Type Plasminogen Activatorprotein-protein interactionssmall moleculesurokinase receptorvirtual screening

Identifiers

PMID28960868
PMCPMC6067920
OpenAlexW2758868811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.