ArticleHuman brain mapping2018
Preserved cortical asymmetry despite thinner cortex in children and adolescents with prenatal alcohol exposure and associated conditions.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Recent breakthroughs in understanding the cerebellum's role in fetal alcohol spectrum disorder: A systematic review.Alcohol (Fayetteville, N.Y.) · 2024Pooled it
- Effectiveness of brief alcohol interventions for pregnant women: a systematic literature review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2026Article
- Prenatal alcohol exposure alters brain structure and neurocognitive outcomes for 6- to 7-year-old children in a South African birth cohort.Alcohol, clinical & experimental research · 2025Article
- Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025Review
- Anxiety and Depression and Sleep Problems Among Patients with Fetal Alcohol Spectrum Disorders.Children (Basel, Switzerland) · 2024Article
- Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.Frontiers in human neuroscience · 2024Article
- Enhancing fetal alcohol spectrum disorders diagnosis with a classifier based on the intracerebellar gradient of volumetric undersizing.Human brain mapping · 2023Article
- [Notch signaling pathway inhibitor DAPT improves alcohol-induced neuronal differentiation impairment in zebrafish].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex.eLife · 2023Article
- Brain structural differences in children with fetal alcohol spectrum disorder and its subtypes.Frontiers in neuroscience · 2023Article
- Spectral-based thickness profiling of the corpus callosum enhances anomaly detection in fetal alcohol spectrum disorders.Frontiers in neuroscience · 2023Article
- High-resolution imaging in studies of alcohol effect on prenatal development.Advances in drug and alcohol research · 2023Article
- The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort.Alcoholism, clinical and experimental research · 2022Article
- Review
- Alcohol's Impact on the Fetus.Nutrients · 2021Review
- Article
- Social behaviors and gray matter volumes of brain areas supporting social cognition in children and adolescents with prenatal alcohol exposure.Brain research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal alcohol exposure (PAE) is associated with reduced overall brain volume. Although this has been reported consistently across studies, the status of cortical thickness after PAE is more variable. The cortex is asymmetric in typical controls, but it is unclear whether the left and right counter parts of the cortical gray matter are unevenly influenced in postpartum brain development after PAE. Brain MRI was acquired in a newly recruited sample of 157 participants (PAE: N = 78, 5.5-18.9 years, 40 females and controls: N = 79, 5.8-18.5 years, 44 females) across four Canadian sites in the NeuroDevNet project. The PAE group had other confounds such as psychiatric co-morbidity, different living environment, and so on, not present in the control group. In agreement with previous studies, the volumes of all brain structures were reduced in PAE compared to controls, including gray and white matter of cerebrum and cerebellum, and all deep gray matter including the hippocampus, amygdala, thalamus, caudate, putamen, and pallidum. The PAE group showed reductions in global and regional cortical thickness, while the pattern and degree of cortical thickness asymmetry were preserved in PAE participants with the greatest rightward asymmetry in the lateral parietal lobe and the greatest leftward asymmetry in the lateral frontal cortex. This persistent asymmetry reflects that the homologous left and right cortical regions followed typical relative developmental patterns in the PAE group despite being thinner bilaterally than controls. Hum Brain Mapp 39:72-88, 2018. © 2017 Wiley Periodicals, Inc.
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