ArticleBrain pathology (Zurich, Switzerland)2018
Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease.
Article in Brain pathology (Zurich, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Associations of pathologic Parkinson's disease (PD) and co-pathologies with cognitive decline and progression of parkinsonian signs in decedents with subclinical disease.Acta neuropathologica · 2025Article
- Parkinson's disease in the spinal cord: An exploratory study to establish T2*w, MTR and diffusion-weighted imaging metric values.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- In vivo effect of LATE-NC on integrity of white matter connections to the hippocampus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Parkinson's Disease and Other Alzheimer's Disease and Related Dementia Pathologies and the Progression of Parkinsonism in Older Adults.Journal of Alzheimer's disease : JAD · 2024Article
- Correlated decline of cognitive and motor phenotypes and ADRD pathologies in old age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Alzheimer's Disease Pathology Outside of the Cerebrum Is Related to a Higher Odds of Dementia.Journal of Alzheimer's disease : JAD · 2023Article
- Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study.Acta neuropathologica communications · 2022Article
- Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment.Frontiers in human neuroscience · 2022Article
- The unique effect of TDP-43 on hippocampal subfield morphometry and cognition.NeuroImage. Clinical · 2022Article
- Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents.Neurology · 2021Article
- Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD.Journal of neurology · 2019Article
- Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies.Neurology · 2019Article
- In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies.Neurobiology of aging · 2019Article
- Spinal motor neurons and motor function in older adults.Journal of neurology · 2019Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
To test the hypothesis that Lewy body pathology (LBs) is present in the spinal cord of older community-dwelling adults without a clinical diagnosis of Parkinson's disease (PD). We studied 162 prospective autopsies from older adults with PD (N = 6) and without PD (N = 156). We documented the presence of LBs in cerebrum and brainstem structures from each of the six regions used for Braak PD staging and four spinal cord levels (C5/6, T7, L4/5 and S4/5). Parkinsonism proximate to death was based on a previously validated measure present if two or more of the four signs of parkinsonism were present based on a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS). Fifty-three of 156 individuals without PD (34%) had LBs in a least one site within the CNS. About half of cases with LBs in the cerebrum or brainstem, (25/53, 47%) also had spinal LBs. Almost 90% (22/25, 88%) of cases with spinal LBs had LBs in the cerebrum (Braak stages 4-6) and about 10% (3/25, 12%) had only brainstem LBs (Braak stages 1-3). Four of six cases with PD showed LBs in cerebrum, brainstem and spinal cord. Individuals with LBs in the spinal cord were more likely to have clinical parkinsonism proximate to death compared to individuals with LBs in brainstem and cerebrum alone (52% vs. 32%; Chi-Square x
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Registered trials
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