SynthesisInternational journal of cancer2018
Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.International journal of cancer · 2019Pooled it
- Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients.International journal of molecular sciences · 2020Trial
- Genetic risk factors modulate the association between physical activity and colorectal cancer.BMC medicine · 2026Article
- Genetic risk factors modulate the association between physical activity and colorectal cancer.Research square · 2025Article
- Three-dimensional genome landscape of primary human cancers.Nature genetics · 2025Article
- Common and novel haplotype structures between different types of cancer.Cancer reports (Hoboken, N.J.) · 2024Article
- LncRNA CASC19: a novel oncogene involved in human cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
- Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D.Frontiers in psychiatry · 2023Review
- Examining the Factors That Affect the Diagnosis of Patients with Positive Fecal Occult Blood Test Results.International journal of environmental research and public health · 2022Article
- Genomic landscape of colorectal carcinogenesis.Journal of cancer research and clinical oncology · 2022Review
- Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen.Frontiers in oncology · 2022Article
- Genotypic and Phenotypic Characteristics of Hereditary Colorectal Cancer.Annals of coloproctology · 2021Review
- Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility.Archives of toxicology · 2021Article
- SNPs associated with colorectal cancer at 15q13.3 affect risk enhancers that modulate GREM1 gene expression.Human mutation · 2021Article
- Factors affecting the follow-up time after a positive result in the fecal occult blood test.PloS one · 2021Article
- Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.Cancer medicine · 2020Article
- LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium.Cancer research · 2020Article
- Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.Cancer medicine · 2020Article
- Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms: A Pooled, Nested, Case-Control Study.JNCI cancer spectrum · 2020Article
- miRNAs-Based Molecular Signature forJournal of immunology research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 20 institutions in 9 countries.
Tomas TanskanenDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4541-1810
Linda van den BergDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Niko VälimäkiDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Mervi AavikkoDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Eivind Ness-JensenHUNT Research Centre, Department of Public Health, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Kristian HveemHUNT Research Centre, Department of Public Health, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Yvonne WettergrenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Elinor Bexe LindskogDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Neeme TõnissonEstonian Genome Center, University of Tartu, Tartu, Estonia.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Kaisa SilanderNational Institute for Health and Welfare, Helsinki, Finland.
Giulia OrlandoDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-9663-4611
Sari TuupanenDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Alexandra E GylfeDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Ulrika A HänninenDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Tatiana CajusoDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Johanna KondelinDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Antti-Pekka SarinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Pekka JousilahtiNational Institute for Health & Welfare, Helsinki, Finland.
Veikko SalomaaNational Institute for Health & Welfare, Helsinki, Finland.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Heikki JärvinenDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
Laura Renkonen-SinisaloDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
Anna LepistöDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
Jan BöhmDepartment of Pathology, Central Finland Central Hospital, Jyväskylä, Finland.
Jukka-Pekka MecklinDepartment of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä, Finland.
Nada A Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Claire PallesWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, United Kingdom.
Lynn MartinInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Ella BarclayWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, United Kingdom.
Albert TenesaColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Susan M FarringtonColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Maria N TimofeevaColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Brian F MeyerDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Salma M WakilDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Christopher G SmithDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Shelley IdziaszczykDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Tim S MaughanCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Richard KaplanMRC Clinical Trials Unit, , Aviation House, London, United Kingdom.
Rachel KerrOxford Cancer Centre, Department of Oncology, University of Oxford, Churchill Hospital, Oxford, United Kingdom.
David KerrNuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Daniel D BuchananColorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0003-2225-6675
Aung K WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-2794-5261
John HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
Mark A JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA.
Steve GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
David ContiDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA.
Fredrick R SchumacherDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Jeremy P CheadleDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Malcolm G DunlopColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Ian P TomlinsonInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Kimmo PalinDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Lauri A AaltonenDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIThe University of Melbourne · AUCardiff University · GBFinnish Institute for Health and Welfare · FIInstitute of Cancer Research · GBKing Faisal Specialist Hospital & Research Centre · SAWestern General Hospital · GBCancer Research UK Clinical Trials Unit · GBCentre for Human Genetics · GBEstonian Biocentre · EEUniversity of Gothenburg · SEBroad Institute · USCase Western Reserve University · USCentral Finland Health Care District · FIChurchill Hospital · GBFred Hutch Cancer Center · USJohn Radcliffe Hospital · GBKarolinska University Hospital · SEMount Sinai Hospital · CAMRC Clinical Trials Unit at UCL · GB
Funding
USC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MColon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3MTransdisciplinary Studies of Genetic Variation in Colorectal CancerU19CA148107 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2010 to 2014
$11.1MFAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1MInherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4MThe Colon Cancer Family Registry: USC ConsortiumU24CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 2008 to 2011
$7.6MGenomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MAUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9MCancer Research UK 12076Cancer Research UK 13154Cancer Research UK 15116Cancer Research UK 16459Cancer Research UK 18927Medical Research Council G0600237Medical Research Council G0600329Medical Research Council G1001799Medical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1Medical Research Council MC_UU_12023/20Medical Research Council MC_UU_12023/3Medical Research Council MR/K014781/1Medical Research Council MR/K018647/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA167551NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551
Abstract
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10
Indexed as
Case-Control StudiesCohort StudiesColorectal NeoplasmsEstoniaFinlandGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRegistriescolorectal cancergenetic predisposition to diseasegenome-wide association studysingle-nucleotide polymorphism
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