Evidence map›Paper›PMID 28960245›Full record

ArticleBiometrics2018

Fully Bayesian spectral methods for imaging data.

Brian J Reich, Joseph Guinness, Simon N Vandekar, Russell T Shinohara, Ana-Maria Staicu

Abstract read
In one paragraph

Article in Biometrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brian J ReichNorth Carolina State University, Raleigh, North Carolina, U.S.A.ORCID 0000-0002-5473-120X
Joseph GuinnessNorth Carolina State University, Raleigh, North Carolina, U.S.A.
Simon N VandekarUniversity of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Russell T ShinoharaUniversity of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Ana-Maria StaicuNorth Carolina State University, Raleigh, North Carolina, U.S.A.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Statistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8M
Mental Health Biostatistics Training ProgramT32MH065218 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BILKER, WARREN B. · 2003 to 2018
$1.3M
Spatiotemporal Modeling of MRI Brain Lesion Trajectories of Biomarker DiscoveryR21NS093349 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ELOYAN, ANI, SHINOHARA, RUSSELL TAKESHI · 2016 to 2017
$454k
NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NIMH NIH HHS T32 MH065218NINDS NIH HHS R01 NS085211NINDS NIH HHS R21 NS093349
6 · The paper itself

Abstract

Medical imaging data with thousands of spatially correlated data points are common in many fields. Methods that account for spatial correlation often require cumbersome matrix evaluations which are prohibitive for data of this size, and thus current work has either used low-rank approximations or analyzed data in blocks. We propose a method that accounts for nonstationarity, functional connectivity of distant regions of interest, and local signals, and can be applied to large multi-subject datasets using spectral methods combined with Markov Chain Monte Carlo sampling. We illustrate using simulated data that properly accounting for spatial dependence improves precision of estimates and yields valid statistical inference. We apply the new approach to study associations between cortical thickness and Alzheimer's disease, and find several regions of the cortex where patients with Alzheimer's disease are thinner on average than healthy controls.

Indexed as

Bayes TheoremData Interpretation, StatisticalAlzheimer DiseaseCase-Control StudiesCerebral CortexComputer SimulationDatasets as TopicDiagnostic ImagingHumansMarkov ChainsMonte Carlo MethodSpectrum AnalysisFunctional connectivityMarkov chain Monte CarloMatérn correlationShrinkage priorsSpherical harmonics

Identifiers

PMID28960245
PMCPMC5874158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.