ArticleInternational journal of oral science2017
Regular nicotine intake increased tooth movement velocity, osteoclastogenesis and orthodontically induced dental root resorptions in a rat model.
Article in International journal of oral science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effect of nicotine exposure on the rate of orthodontic tooth movement: A meta-analysis based on animal studies.PloS one · 2021Pooled it
- Effects of testosterone and high-dose anabolic steroids on orthodontic-induced bone remodeling and root resorption: An animal study.Journal of periodontology · 2026Article
- Pharmacological Modulation of Orthodontic Tooth Movement: Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. A Review.Clinical, cosmetic and investigational dentistry · 2026Review
- The effects of low-yield nicotine cigarette smoke inhalation on orthodontic tooth movement.Korean journal of orthodontics · 2025Article
- Nicotine-induced Genetic and Epigenetic Modifications in Primary Human Amniotic Fluid Stem Cells.Current pharmaceutical design · 2024Article
- Influence of E-Cigarette and Cannabis Vaping on Orthodontically Induced Tooth Movement and Periodontal Health in Patients Undergoing Orthodontic Therapy.International journal of environmental research and public health · 2022Article
- Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs.Drug design, development and therapy · 2022Article
- Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway.Journal of dental research · 2021Article
- Compressive force strengthened the pro-inflammatory effect of zoledronic acid on il-1ß stimulated human periodontal fibroblasts.Clinical oral investigations · 2021Article
- Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement.Biomedicines · 2020Article
- Effects of sodium chloride on the gene expression profile of periodontal ligament fibroblasts during tensile strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2020Article
- Orthodontic cell stress modifies proinflammatory cytokine expression in human PDL cells and induces immunomodulatory effects via TLR-4 signaling in vitro.Clinical oral investigations · 2020Article
- Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity.Tobacco induced diseases · 2020Review
- The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain-an in vitro study of human periodontal ligament fibroblasts.International journal of oral science · 2019Article
- Three-dimensional analysis of the physiologic drift of adjacent teeth following maxillary first premolar extractions.Scientific reports · 2019Article
- Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain.Mediators of inflammation · 2019Article
- Article
- Expression kinetics of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2018Article
- Tobacco-induced suppression of the vascular response to dental plaque.Molecular oral microbiology · 2018Review
- Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each (A/B/C) to 3 experimental groups (7 rats, 1/2/3): (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C) reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR)/cotinine serology-(1) control; (2) orthodontic tooth movement (OTM) of the first and second upper left molar (NiTi closed coil spring, 0.25 N); (3) OTM with 1.89 mg·kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.