Evidence map›Paper›PMID 28960168›Full record

ArticleNanomedicine (London, England)2017

Nanofiber-based sutures induce endogenous antimicrobial peptide.

Shixuan Chen, Liangpeng Ge, Adrian F Gombart, Franklin D Shuler, Mark A Carlson, Debra A Reilly, Jingwei Xie

Open access · greenAbstract read
In one paragraph

Article in Nanomedicine (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Electrospun Nanofibers for Wound Management.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2022
    Article
  5. Review
  6. Article
  7. Eluted 25-hydroxyvitamin DActa biomaterialia · 2019
    Article
  8. Article
  9. 1α,25-dihydroxyvitamin DNanomedicine (London, England) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Shixuan ChenDepartment of Surgery-Transplant & Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Liangpeng GeChongqing Academy of Animal Sciences & Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, China.
Adrian F GombartDepartment of Biochemistry & Biophysics & Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Franklin D ShulerDepartment of Orthopedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Mark A CarlsonDepartment of Surgery-General Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Debra A ReillyDepartment of Surgery-Plastic Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jingwei XieDepartment of Surgery-Transplant & Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USChongqing Academy of Animal Science · CNMarshall University · USOregon State University · US

Funding

Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Nanofiber-based Delivery of Combined Immune-modulating Compounds to Minimize Infection and Enhance Wound HealingR01GM123081 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIE, JINGWEI · 2017 to 2024
$2.8M
NIGMS NIH HHS P20 GM103480NIGMS NIH HHS R01 GM123081
6 · The paper itself

Abstract

aimThe aim of this study was to develop nanofiber-based sutures capable of inducing endogenous antimicrobial peptide production.

methodsWe used co-axial electrospinning deposition and rolling to fabricate sutures containing pam3CSK4 peptide and 25-hydroxyvitamin D

resultsThe diameters and mechanical properties of the sutures were adjustable to meet the criteria of United States Pharmacopeia designation. 25D

conclusionThe use of 25D

Indexed as

SuturesAntimicrobial Cationic PeptidesBiomechanical PhenomenaCalcifediolCathelicidinsCell LineCell ProliferationDrug CarriersDrug LiberationFibroblastsHumansKeratinocytesLipopeptidesNanofibersParticle SizeSkinAntimicrobial Cationic PeptidesCalcifediolCathelicidinsDrug CarriersLipopeptidesPam(3)CSK(4) peptide25-hydroxyvitamin D3co-deliveryelectrospun nanofiberspam3Cys-Ser-(Lys)4 peptidesurgical site infectionsutures

Identifiers

PMID28960168
PMCPMC5674207
OpenAlexW2757309184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.