ArticleJournal of Korean medical science2017
Is Frailty a Modifiable Risk Factor of Future Adverse Outcomes in Elderly Patients with Incident End-Stage Renal Disease?
Article in Journal of Korean medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The prevalence of frailty among older adults with maintenance hemodialysis: a systematic.BMC nephrology · 2025Pooled it
- Association between frailty and adverse outcomes in patients undergoing maintenance hemodialysis: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Dialysis or kidney transplantation in older adults? A systematic review summarizing functional, psychological, and quality of life-related outcomes after start of kidney replacement therapy.International urology and nephrology · 2022Pooled it
- Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Risk factors for mortality in elderly haemodialysis patients: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Frailty and mortality among patients with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis.International urology and nephrology · 2020Pooled it
- Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis.Kidney medicine · 2025Article
- Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Development of a Lasso-Nomogram-Based Risk Prediction Model for Cognitive Frailty in Elderly MHD Patients.Neuropsychiatric disease and treatment · 2025Article
- Prevalence and risk factors of pre-frailty and frailty in hemodialysis patients in central China.Scientific reports · 2024Article
- Short-term and long-term survival in patients with prevalent haemodialysis-an integrated prognostic model: external validation.BMJ supportive & palliative care · 2024Article
- Prevalence and associated factors of frailty in patients with chronic kidney disease: a cross-sectional analysis of PEAKING study.International urology and nephrology · 2024Article
- Trends in Frailty Prevalence Among Older Adults in Korea: A Nationwide Study From 2008 to 2020.Journal of Korean medical science · 2023Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Article
- Association between physical performance and incidence of end-stage renal disease in older adults: a national wide cohort study.BMC nephrology · 2021Article
- Severity of frailty as a significant predictor of mortality for hemodialysis patients: a prospective study in China.International journal of medical sciences · 2021Observational
- Frailty Assessment in Patients with Liver Cirrhosis.Clinical liver disease · 2019Review
- Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review.Therapeutic advances in chronic disease · 2019Article
- Potential Role of Psychosocial Factors on Health-Related Quality of Life in Hemodialysis Patients.Journal of Korean medical science · 2018Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Little is known about the clinical significance of frailty and changes of frailty after dialysis initiation in elderly patients with end-stage renal disease (ESRD). We prospectively enrolled 46 elderly patients with incident ESRD at a dialysis center of a tertiary hospital between May 2013 and March 2015. Frailty was assessed by using a comprehensive geriatric assessment protocol and defined as a multidimensional frailty score of ≥ 10. The main outcome was the composite of all-cause death or cardiovascular hospitalization, as determined in June 2016. The median age of the 46 participants was 71.5 years, and 63.0% of them were men. During the median 17.7 months follow-up, the rate of composite outcome was 17.4%. In multivariate logistic regression analysis, after adjusting for age, sex, diabetes, body mass index (BMI), and time of predialytic nephrologic care, female sex, and increased BMI were associated with increased and decreased odds of frailty, respectively. In multivariate Cox proportional hazards analysis, after adjusting for age, sex, diabetes, BMI, and time of predialytic nephrologic care, frailty was significantly associated with the composite adverse outcome. In repeated frailty assessments, the multidimensional frailty score significantly improved 12 months after the initiation of dialysis, which largely relied on improved nutrition. Therefore, frailty needs to be assessed for risk stratification in elderly patients with incident ESRD.
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