Evidence map›Paper›PMID 28959658›Full record

ArticleToxicology reports2017

Comparison of diglycolic acid exposure to human proximal tubule cells

Miriam E Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. 28-day repeated dose response study of diglycolic acid: Renal and hepatic effects.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miriam E MossobaU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Sanah VohraU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Howard ToomerU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Shelia Pugh-BishopU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Zachary KeltnerU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Vanessa ToppingU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Thomas BlackU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Nicholas OlejnikU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Ana DepinaU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Kathleen BelgraveU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Jessica SprandoU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Joyce NjorgeU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Thomas J FlynnU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Paddy L WiesenfeldU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.
Robert L SprandoU.S. Food and Drug Administration (US FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), 8301 Muirkirk Rd., Laurel, MD 20708, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diglycolic acid (DGA) is present in trace amounts in our food supply and is classified as an indirect food additive linked with the primary GRAS food additive carboxymethyl cellulose (CMC). Carboxymethyl starches are used as a filler/binder excipient in dietary supplement tablets and a thickening ingredient in many other processed foods. We sought to utilize the human proximal tubule HK-2 cell line as an

Indexed as

DGA, diglycolic acidDiglycolic acidHK-2 cellsKidney proximal tubuleKIM-1, Kidney Injury Molecule-1MMP, mitochondrial membrane potentialNephrotoxicityROS, reactive oxygen species

Identifiers

PMID28959658
PMCPMC5615145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.