ArticleToxicology reports2017
8-Hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to low-dose benzene.
Article in Toxicology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- The impact of physical exercise on genotoxicity in older adults: a systematic review.Biogerontology · 2025Pooled it
- mRNA Rather than Protein Expression of Hepatic Selenoprotein H is More Sensitive to Short-term Low Aflatoxin BBiological trace element research · 2026Article
- Dietary cauliflower (Brassica oleracea var. botrytis) mitigates benzo[a]pyrene-induced oxidative stress, immune dysfunction, and tissue damage in Nile tilapia.Scientific reports · 2026Article
- Comparing Differences in Blood Malondialdehyde and Risk Factors Among Four Occupations Around an Industrial Estate, Rayong Province of Thailand.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study.BMC public health · 2025Article
- Protective effects of chlorogenic acid against glyphosate-induced organ and blood toxicity in Wistar rats.Arhiv za higijenu rada i toksikologiju · 2025Article
- Mitochondrial Dysfunction in Systemic Lupus Erythematosus: Insights and Therapeutic Potential.Diseases (Basel, Switzerland) · 2024Review
- Analyses of oxidative DNA damage among coal vendors via single cell gel electrophoresis and quantification of 8-hydroxy-2'-deoxyguanosine.Molecular and cellular biochemistry · 2024Article
- Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay.International journal of environmental research and public health · 2022Article
- Health consequences of disinfection against SARS-CoV-2: Exploring oxidative stress damage using a biomonitoring approach.The Science of the total environment · 2022Article
- Urinary 8-OHdG level is not affected by geography and trace elements in nail of residents of Addis Ababa: It is shaped by interactions between different social factors.Toxicology reports · 2022Article
- Effect of low-level laser irradiation on cytotoxicity of benzene in human normal fibroblast cells.Lasers in medical science · 2021Article
- Study on the neuroprotective effects of Genistein on Alzheimer's disease.Brain and behavior · 2021Review
- Biomarkers of Low-Level Environmental Exposure to Benzene and Oxidative DNA Damage in Primary School Children in Sardinia, Italy.International journal of environmental research and public health · 2021Article
- Isoprostanes in Veterinary Medicine: Beyond a Biomarker.Antioxidants (Basel, Switzerland) · 2021Review
- The EU endocrine disruptors' regulation and the glyphosate controversy.Toxicology reports · 2021Article
- Association of Tumour Microenvironment with Protein Glycooxidation, DNA Damage, and Nitrosative Stress in Colorectal Cancer.Cancer management and research · 2021Article
- Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in BToxicology reports · 2021Article
- Toxicity assessment of electrochemical advanced oxidation process-treated groundwater from a gas station with petrochemical contamination.Environmental monitoring and assessment · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aims to investigate the relation between exposure to low-dose benzene and the occurrence of oxidative DNA damage in gasoline station workers, as well as the possible role of interfering or confounding factors. Urine levels of 8-OHdG were evaluated by a competitive immunoassay in a group of 80 men, employed in gasoline stations located in East Sicily and compared with a control group (n = 63) of male office employees not occupationally exposed to benzene. Information regarding socio-demographic characteristics, lifestyle and job-related records were provided through a questionnaire. Significantly higher (p < 0.05) urinary t,t,-MA and 8-OHdG levels were observed in gasoline station attendants compared to subjects not exposed to benzene. Pearson's test demonstrated a strong correlation (r = 0.377, p < 0.001) between 8-OHdG and benzene exposure level. 8-OHdG significantly correlated also with job seniority, (r = 0.312, p < 0.01), whereas the relation with age resulted weaker (r = 0.242, p < 0.05). Multiple linear regression analysis, performed to exclude a role for confounding factors, showed that variables like gender, smoking habit, alcohol consumption and BMI did not have a significant influence on the measured biomarkers. No subject enrolled in the study presented signs or symptoms of work-related disease or other illness linked to oxidative stress. These results suggest that low-level chronic exposure to benzene among gasoline station attendants can determine oxidative damage on DNA, as indicated by alteration of 8-OHdG which may represent a non-invasive biomarker of early genotoxic damage in exposed subjects.
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