ArticleToxicology reports2017
Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats.
Article in Toxicology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Evaluating the effect of γ-oryzanol on MASLD pathology using a medaka fish model.FEBS open bio · 2026Article
- Media Supplementation With Gamma-Oryzanol Improves the Outcome of Ovine Oocyte Maturation In Vitro.Veterinary medicine and science · 2025Article
- Gamma-oryzanol dose optimization in maturation or culture media forIranian journal of veterinary research · 2023Article
- Effects of γ-oryzanol on motor function in a spinal cord injury model.Translational neuroscience · 2023Article
- Article
- Spice fixed oils as a new source of γ-oryzanol: nutraceutical characterization of fixed oils from selected spices.RSC advances · 2020Article
- ORY supplementation mitigates acetaminophen-induced acute liver failure in male mice: role of oxidative stress and apoptotic markers.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats.Toxicology reports · 2020Article
- Article
- Ameliorative effect of gallic acid in paclitaxel-induced neuropathic pain in mice.Toxicology reports · 2019Article
- A toxicity profile of the Pheroid® technology in rodents.Toxicology reports · 2019Article
- Phytosterol-based edible oleogels: A novel way of replacing saturated fat in food.Nutrition bulletin · 2018Article
- Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 90-day oral toxicity study of γ-oryzanol, a rice-derived triterpenoid ferulate, was performed by oral gavage administration to male and female Sprague-Dawley rats at doses of 0, 1000, and 2000 mg/kg body weight/day. All rats administered γ-oryzanol survived throughout the study period. Both male and female rats showed no toxicologically significant changes of the general signs, examination findings, body weight, food consumption, functional observational battery results, ophthalmological findings, urinalysis, hematology tests, clinical chemistry tests, organ weights, and necropsy findings. Moreover, there were no histopathological changes related to administration of γ-oryzanol in males and females from the 2000 mg/kg body weight/day group. In conclusion, the no observed adverse effect level (NOAEL) of γ-oryzanol exceeded 2000 mg/kg body weight/day for both male and female rats under the conditions of this study.
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