ArticleToxicology reports2016
Effect of a controlled food-chain mediated exposure to cadmium and arsenic on oxidative enzymes in the tissues of rats.
Article in Toxicology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Bio and Geno-toxic Activities of Cadmium- Arsenic Salts Combination And/or Fluoride in Female Rats Confirmed by Molecular Docking.Biological trace element research · 2026Article
- Metal-based triazoles as a medical marvel of the modern era: a comprehensive review.RSC advances · 2026Review
- Zinc and selenium attenuate quaternary heavy metal mixture-induced testicular damage via amplification of the antioxidant system, reduction in metal accumulation, inflammatory and apoptotic biomarkers.Toxicological research · 2023Article
- Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails.Biological trace element research · 2021Article
- Transcriptome sequencing reveals genes involved in cadmium-triggered oxidative stress in the chicken heart.Poultry science · 2021Article
- Review of Cadmium Pollution in Bangladesh.Journal of health & pollution · 2019Review
- Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes.Toxicology reports · 2019Article
- Influence of farmyard manure on some morphological and biochemical parameters of cowpea (Vigna unguiculata) seedling grown in cadmium-treated soil.Environmental science and pollution research international · 2017Article
- Effect of arsenic acid withdrawal on hepatotoxicity and disruption of erythrocyte antioxidant defense system.Toxicology reports · 2017Article
- Exposure of the endangered Milky stork population to cadmium and lead via food and water intake in Kuala Gula Bird Sanctuary, Perak, Malaysia.Toxicology reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aims to investigate the effect of cadmium and arsenic through a controlled food chain on the activities of some oxidative enzymes (Sulphite oxidase SO, Aldehyde oxidase AO, Monoamine oxidase MO and Xanthine oxidase, XO) in the liver, kidney, testes, heart and brain of rats. MATERIALS AND
methodsFish (the first trophic level) were exposed to both metals (singly and in mixture) using cadmium chloride (CdCl
resultsMetal analysis on the tissues of rats showed that the metals accumulated more in the liver than in other organs after the 1 month exposure but accumulated more in the kidney after the 3 months exposure. The activities of the oxidative enzymes in the liver were significantly (P < 0.05) decreased in all test groups after the 1 and 3 months exposure. However, after the 1 month exposure, the kidney, testes and heart showed an initial increase in the activities of these enzymes which were decreased after the 3 months exposure. In the brain, the activities of these enzymes were increased in both duration of study.
conclusionFrom the results obtained in the current study, it could be concluded that exposure to cadmium and arsenic through the food chain leads to accumulation of these metals in the tissues of experimental rats leading to the inhibition of oxidative enzymes, thus affecting several normal metabolic processes.
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