Evidence map›Paper›PMID 28959560›Full record

ArticleToxicology reports2016

Genetic and rat toxicity studies of cyclodextrin glucanotransferase.

Robert R Maronpot, Cheryl A Hobbs, Jeffrey Davis, Carol Swartz, Molly Boyle, Mihoko Koyanagi, Shim-Mo Hayashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert R MaronpotMaronpot Consulting LLC, 1612 Medfield Road, Raleigh, NC 27607, USA.
Cheryl A HobbsIntegrated Laboratory Systems, Inc., PO Box 13501, Research Triangle Park, NC 27709, USA.
Jeffrey DavisIntegrated Laboratory Systems, Inc., PO Box 13501, Research Triangle Park, NC 27709, USA.
Carol SwartzIntegrated Laboratory Systems, Inc., PO Box 13501, Research Triangle Park, NC 27709, USA.
Molly BoyleIntegrated Laboratory Systems, Inc., PO Box 13501, Research Triangle Park, NC 27709, USA.
Mihoko KoyanagiGlobal Scientific & Regulatory Affairs, San-Ei Gen F.F.I., Inc., 1-1-11 Sanwa-cho, Toyonaka, Osaka 561-8588, Japan.
Shim-Mo HayashiGlobal Scientific & Regulatory Affairs, San-Ei Gen F.F.I., Inc., 1-1-11 Sanwa-cho, Toyonaka, Osaka 561-8588, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMicrobiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing agent in manufacture of food, pharmaceuticals, and cosmetics. Its toxic potential was evaluated in anticipation of use in the production of

methodsFollowing OECD guidelines, CGTase, produced by

resultsCGTase did not induce mutations with or without metabolic activation in the bacterial reverse mutation assay. Formation of micronuclei was not induced in either

conclusionThe genotoxicity assays and repeated dose toxicity study support the safe use of CGTase in production of

Indexed as

CGTase, cyclodextrin glucanotransferaseComet assayEFSA, European Food Safety AuthorityEMIQ, enzymatically modified isoquercitrinEnzymatically modified isoquercitrin (EMIQ)FlavonolFood additiveGLP, good laboratory practiceMicronucleus assayMN, micronucleiM N-NCE, micronucleated normochromatic erythrocytesMN-RET, micronucleated reticulocytesNOAEL, no observed adverse effect levelOECD, Organization for Economic Co-operation and DevelopmentSodium sulfateSodium sulfate (PubChem CID: 24436)

Identifiers

PMID28959560
PMCPMC5615836

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.