Evidence map›Paper›PMID 28959504›Full record

ReviewCurrent radiology reports2016

Imaging Features of Toxicities by Immune Checkpoint Inhibitors in Cancer Therapy.

Gerlig Widmann, Van Anh Nguyen, Julian Plaickner, Werner Jaschke

Abstract readReview
In one paragraph

Review in Current radiology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Review
  3. Immune checkpoint inhibitor-induced diarrhea and colitis: an overview.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Immunotherapy-induced Hepatotoxicity: A Review.Journal of clinical and translational hepatology · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Immunotherapy-Mediated Luminal Gastrointestinal Toxicities.Advances in experimental medicine and biology · 2021
    Article
  19. Article
  20. Hepatobiliary and Pancreatic Adverse Events.Advances in experimental medicine and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerlig WidmannDepartment of Radiology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.
Van Anh NguyenDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.
Julian PlaicknerDepartment of Radiology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.
Werner JaschkeDepartment of Radiology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWith the increasing use of immune checkpoint inhibitors in cancer therapy radiographic profiling of frequent and serious immune-related adverse events (irAEs) becomes more relevant. This article reviews imaging features of irAEs induced by the anti-CTLA-4 and anti-PD-1 antibodies ipilimumab, nivolumab and pembrolizumab. RECENT

findingsImportant radiological manifestations are immune-related colitis, hepatitis, pancreatitis, hypophysitis, pneumonitis, arthritis and sarcoid-like lymphadenopathy. Typical imaging features are summarized and compared with other relevant differential diagnoses. SUMMARY: Early diagnosis and appropriate therapeutic decisions are required for a successful treatment of irAEs. In addition to staging and follow-up imaging, identification and monitoring of adverse events becomes an important radiologic aspect in oncologic care.

Indexed as

ImagingImmune checkpoint inhibitorsImmune-related adverse events

Identifiers

PMID28959504
PMCPMC5594046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.