ArticleStroke and vascular neurology2017
Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke.
Article in Stroke and vascular neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Blood pressure variability predicts poor outcomes in acute stroke patients without thrombolysis: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Anaesthesia modality on endovascular therapy outcomes in patients with large infarcts: a post hoc analysis of the ANGEL-ASPECT trial.Stroke and vascular neurology · 2025Trial
- Trial
- Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study.Journal of human hypertension · 2019Trial
- Impact of Systolic Blood Pressure Trajectories and Variability on Unexplained Early Neurological Deterioration Post-Endovascular Treatment in Acute Ischemic Stroke Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- Overall and linked blood pressure variabilities in the first 24 hours and mortality after spontaneous intracerebral hemorrhage: a retrospective study of 1,036 patients.Anesthesia and pain medicine · 2024Article
- Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Beat-to-Beat Blood Pressure Variability Within 24 Hours of Ischemic Stroke Onset: A Potential Predictor of Functional Prognosis.Journal of the American Heart Association · 2024Article
- Association of systolic blood pressure variability with remote ischemic conditioning in acute ischemic stroke.Scientific reports · 2024Article
- Article
- Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring.Journal of clinical hypertension (Greenwich, Conn.) · 2024Observational
- Machine learning models reveal the critical role of nighttime systolic blood pressure in predicting functional outcome for acute ischemic stroke after endovascular thrombectomy.Frontiers in neurology · 2024Article
- Blood pressure variability and early neurological outcomes in acute and subacute stroke in Southwestern Uganda.eNeurologicalSci · 2023Article
- Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice.Cellular and molecular neurobiology · 2023Article
- Blood Pressure Variability Indices for Outcome Prediction After Thrombectomy in Stroke by Using High-Resolution Data.Neurocritical care · 2022Article
- Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Factors affecting physician decision-making regarding antiplatelet therapy in minor ischemic stroke.Frontiers in neurology · 2022Article
- Hemodynamics of Leptomeningeal Collaterals after Large Vessel Occlusion and Blood Pressure Management with Endovascular Treatment.Journal of stroke · 2021Review
- An update on hyper-acute management of ischaemic stroke.Clinical medicine (London, England) · 2021Review
- Adverse Outcomes Associated With Higher Mean Blood Pressure and Greater Blood Pressure Variability Immediately After Successful Embolectomy in Those With Acute Ischemic Stroke, and the Influence of Pretreatment Collateral Circulation Status.Journal of the American Heart Association · 2021Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionIncreased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored.
methodsWe retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (mRS) 30-365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to mRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score.
results110 patients met the inclusion criteria. The likelihood of a 1-point rise in the mRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels.
conclusionsThese results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV.
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