ArticleChemical science2017
Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Evolution and Impact of Imine Reductases (IREDs) Research: A Knowledge Mapping Approach.Molecular biotechnology · 2026Review
- Enantioselective rapid assembly of bis-heterocycles by sequential palladium-catalyzed aza-Heck cyclization coupling reaction.Science advances · 2026Article
- Nitrogen Insertion via Asymmetric Condensation and Chirality Transfer: A Stereodivergent Entry to Cyanocyclopropanes.Angewandte Chemie (International ed. in English) · 2025Article
- Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols.Angewandte Chemie (International ed. in English) · 2024Article
- Asymmetric imino-acylation of alkenes enabled by HAT-photo/nickel cocatalysis.Chemical science · 2023Article
- Heck Macrocyclization in Forging Non-Natural Large Rings including Macrocyclic Drugs.International journal of molecular sciences · 2023Review
- Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines.Molecules (Basel, Switzerland) · 2023Review
- Cyclopropane-FusedJournal of the American Chemical Society · 2022Article
- Homologation of aryl ketones to long-chain ketones and aldehydes via C-C bond cleavage.iScience · 2022Article
- Iminyl radical-triggered relay annulation for the construction of bridged aza-tetracycles bearing four contiguous stereogenic centers.Chemical science · 2022Article
- Article
- Radical Aza-Heck Cyclization of Imidates via Energy Transfer, Electron Transfer, and Cobalt Catalysis.ACS catalysis · 2022Article
- Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis.Chemical reviews · 2022Review
- Electrophilic Aminating Agents in Total Synthesis.Angewandte Chemie (International ed. in English) · 2021Review
- Copper-Catalyzed Aza-Sonogashira Cross-Coupling To Form Ynimines: Development and Application to the Synthesis of Heterocycles.Angewandte Chemie (International ed. in English) · 2021Article
- Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization.Organic letters · 2021Article
- Tandem aza-Heck Suzuki and carbonylation reactions ofChemical science · 2021Article
- Electrochemical Dehydrogenative C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Copper-Mediated Radical-Polar Crossover Enables Photocatalytic Oxidative Functionalization of Sterically Bulky Alkenes.Journal of the American Chemical Society · 2021Article
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4 authors.
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Abstract
Aza-Heck cyclizations are an emerging method for the construction of chiral N-heterocyclic systems. In these processes, an activated N-O bond replaces the C-X bond (X = halide, OTf) used in conventional Heck reactions, with the associated aza-Pd(ii)-intermediate engaging pendant alkenes in a Heck-like manner. This perspective article commences with an historical overview of the area, which stems from Narasaka's seminal studies using oxime esters as the initiating motif. The scope and mechanism of associated chiral N-heterocyclic methodologies are then outlined, including cascade processes that enable diverse alkene 1,2-carboaminations. The recent emergence of new N-O donors and the realization of highly enantioselective aza-Heck cyclizations are then discussed. Collectively, these studies suggest that the aza-Heck approach can underpin a broad family of redox-neutral and enantioselective C-N bond forming processes.
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