ArticleFrontiers in endocrinology2017
Longer Telomere Length and its Association with Lower Levels of C-Peptide.
Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Chronic inflammation mediates the relationship between physical activity and telomere length.GeroScience · 2026Article
- Obesity-Senescence-Breast Cancer: Clinical Presentation of a Common Unfortunate Cycle.Advances in experimental medicine and biology · 2024Review
- Insulin and aging - a disappointing relationship.Frontiers in endocrinology · 2023Review
- C-peptide is a predictor of telomere shortening: A five-year longitudinal study.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTelomeres undergo shortening with each cell division, which could be accelerated by increase obesity and is also related to endocrinology systems. In this study, we aimed to examine the complex association between telomere, C-peptide, and obesity as well as chronic inflammation in a large population-based cross-sectional survey.
methodsWe used data from a community-based population study, where around 1,382 participants were recruited and had telomere length measured. The association of telomere length with C-peptide was studied using multiple linear regression models. We also examined if obesity, measured by body mass index (BMI), and inflammation could affect this observed association.
resultsAround 48% of these participants were men and 52% were women. The average ages were 51.7 years old for men and 49.1 years old for women. After controlling for age and sex, 1 U increase of telomere length was associated with -0.17 (-0.28, -0.06) unit decrease of C-peptide. Additionally controlling for BMI, the association magnitude was decreased to -0.13 (-0.23, -0.04). Further adjusting for inflammation biomarker did not change the effect estimates.
conclusionLonger telomere was associated with lower levels of C-peptide. This association could be attenuated by adjusting for obesity.
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