ArticleFrontiers in aging neuroscience2017
Altered Behavioral and Autonomic Pain Responses in Alzheimer's Disease Are Associated with Dysfunctional Affective, Self-Reflective and Salience Network Resting-State Connectivity.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Experimentally evoked pain in Alzheimer's disease.Journal of the American Association of Nurse Practitioners · 2021Pooled it
- A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson's disease.Cognitive neurodynamics · 2026Article
- Electrodermal Activity as a Potential Diagnostic Biomarker for Alzheimer's Disease: A Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Autonomic nervous system flexibility for understanding brain aging.Ageing research reviews · 2023Review
- Chronic pain in Alzheimer's disease: Endocannabinoid system.Experimental neurology · 2023Review
- Feasibility, Acceptability, and Efficacy of Home-Based Transcranial Direct Current Stimulation on Pain in Older Adults with Alzheimer's Disease and Related Dementias: A Randomized Sham-Controlled Pilot Clinical Trial.Journal of clinical medicine · 2023Article
- Documented nursing practices of pain assessment and management when communicating about pain in dementia care.Journal of advanced nursing · 2022Article
- A Cross-Sectional Study of Pain Sensitivity and Unpleasantness in People with Vascular Dementia.Pain medicine (Malden, Mass.) · 2022Article
- Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Policy Implications for Pain in Advanced Alzheimer's Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- Alzheimer's Disease Progressively Reduces Visual Functional Network Connectivity.Journal of Alzheimer's disease reports · 2021Article
- Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging.Frontiers in aging neuroscience · 2021Article
- The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge.Journal of Alzheimer's disease reports · 2020Review
- Dysautonomia in Alzheimer's Disease.Medicina (Kaunas, Lithuania) · 2020Review
- The tetrapartite synapse: a key concept in the pathophysiology of schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2018Review
- A Technical Note on the PainChek™ System: A Web Portal and Mobile Medical Device for Assessing Pain in People With Dementia.Frontiers in aging neuroscience · 2018Article
- Sex Differences in the Psychophysical Response to Contact Heat in Moderate Cognitive Impairment Alzheimer's Disease: A Cross-Sectional Brief Report.Journal of Alzheimer's disease : JAD · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While pain behaviors are increased in Alzheimer's disease (AD) patients compared to healthy seniors (HS) across multiple disease stages, autonomic responses are reduced with advancing AD. To better understand the neural mechanisms underlying these phenomena, we undertook a controlled cross-sectional study examining behavioral (Pain Assessment in Advanced Dementia, PAINAD scores) and autonomic (heart rate, HR) pain responses in 24 HS and 20 AD subjects using acute pressure stimuli. Resting-state fMRI was utilized to investigate how group connectivity differences were related to altered pain responses. Pain behaviors (slope of PAINAD score change and mean PAINAD score) were increased in patients vs. CONTROLS: Autonomic measures (HR change intercept and mean HR change) were reduced in severe vs. mildly affected AD patients. Group functional connectivity differences associated with greater pain behavior reactivity in patients included: connectivity within a temporal limbic network (TLN) and between the TLN and ventromedial prefrontal cortex (vmPFC); between default mode network (DMN) subcomponents; between the DMN and ventral salience network (vSN). Reduced HR responses within the AD group were associated with connectivity changes within the DMN and vSN-specifically the precuneus and vmPFC. Discriminant classification indicated HR-related connectivity within the vSN to the vmPFC best distinguished AD severity. Thus, altered behavioral and autonomic pain responses in AD reflects dysfunction of networks and structures subserving affective, self-reflective, salience and autonomic regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.