Evidence map›Paper›PMID 28959059›Full record

ArticleChemical physics letters2017

Comparative Dynamics of Methionine Side-Chain in FMOC-Methionine and in Amyloid Fibrils.

Liliya Vugmeyster, Dmitry Ostrovsky

Open access · greenAbstract read
In one paragraph

Article in Chemical physics letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Investigation of biomolecular dynamics by sensitivity-enhancedJournal of magnetic resonance open · 2024
    Article
  2. Persistence of Methionine Side Chain Mobility at Low Temperatures in a Nine-Residue Low Complexity Peptide, as Probed byChemphyschem : a European journal of chemical physics and physical chemistry · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Liliya VugmeysterDepartment of Chemistry, 1201 Larimer Street, University of Colorado at Denver, Denver, CO 80204, USA.
Dmitry OstrovskyDepartment of Mathematics, 1201 Larimer Street, University of Colorado at Denver, Denver, CO 80204, USA.
University of Colorado Denver · US

Funding

Variant-specific dynamics of amyloid-b fibrilsR15GM111681 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI VUGMEYSTER, LILIYA · 2014 to 2021
$1.3M
NIGMS NIH HHS R15 GM111681
6 · The paper itself

Abstract

We compared the dynamics of key methionine methyl groups in the water-accessible hydrophobic cavity of amyloid fibrils and Fluorenylmethyloxycarbonyl-Methionine (FMOC-Met), which renders general hydrophobicity to the environment without the complexity of the protein. Met35 in the hydrated cavity was recently found to undergo a dynamical cross-over from the dominance of methyl rotations at low temperatures to the dominance of diffusive motion of methyl axis at high temperatures. Current results indicate that in FMOC-Met this cross-over is suppressed, similar to what was observed for the dry fibrils, indicating that hydration of the cavity is driving the onset of the dynamical transition.

Indexed as

deuterium NMRmethioninemethyl group dynamicsrelaxation timessolids-state NMR

Identifiers

PMID28959059
PMCPMC5612497
OpenAlexW2588136201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.