Evidence map›Paper›PMID 28958903›Full record

ArticleThe Journal of allergy and clinical immunology2018

T

Kyoung Yul Seo, Kazuya Kitamura, Soo Jung Han, Brian Kelsall

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression.Investigative ophthalmology & visual science · 2025
    Article
  4. Ocular surface immune cell diversity in dry eye disease.Indian journal of ophthalmology · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome.International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Kyoung Yul SeoMucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md; Institute for Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Kazuya KitamuraMucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.
Soo Jung HanInstitute for Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Brian KelsallMucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md. Electronic address: bkelsall@niaid.nih.gov.
National Institutes of Health · USYonsei University · KR

Funding

Antigen Processing And Presentation In The IntestineZIAAI000833 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KELSALL, BRIAN · 2009 to 2025
$24.9M
ANTIGEN PROCESSING AND PRESENTATION IN THE INTESTINEZ01AI000833 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KELSALL, BRIAN · 1998 to 2008
$3.0M
Intramural NIH HHS Z01 AI000833
6 · The paper itself

Abstract

backgroundDry eye disease (DED) affects one third of the population worldwide. In prior studies, experimental autoimmune lacrimal keratoconjunctivitis (EALK) induced by desiccating stress in mice has been used as a model of DED. This model is complicated by a requirement for exogenous epithelial cell injury and administration of anticholinergic agents with broad immunologic effects.

objectiveWe sought to develop a novel mouse model of EALK and to demonstrate the responsible pathogenic mechanisms.

methodsCD4

resultsEALK developed spontaneously in C57BL/10 Rag2

conclusionWe describe a novel model of spontaneous EALK that supports a role for T

Indexed as

Disease Models, AnimalAdoptive TransferAnimalsAutoimmune DiseasesCorneaCytokinesHumansInflammationKeratoconjunctivitis SiccaLacrimal ApparatusMiceMice, Inbred C57BLMice, KnockoutPeripheral NervesTearsTh17 CellsCytokinesAutoimmune lacrimal keratoconjunctivitisT(H)17 cell

Identifiers

PMID28958903
PMCPMC6886359
OpenAlexW2758855963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.