ArticleEBioMedicine2017
Lymphopenic Community Acquired Pneumonia (L-CAP), an Immunological Phenotype Associated with Higher Risk of Mortality.
Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Burden of pneumococcal disease among adults in Southern Europe (Spain, Portugal, Italy, and Greece): a systematic review and meta-analysis.Human vaccines & immunotherapeutics · 2021Pooled it
- The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial.Critical care (London, England) · 2023Trial
- Nomogram for prediction of severe community-acquired pneumonia development in diabetic patients: a multicenter study.BMC pulmonary medicine · 2022Trial
- Mucosal-associated invariant T cells and Vδ2Clinical and experimental immunology · 2020Trial
- Trial
- Observational
- Characteristics of CD4Journal of intensive medicine · 2026Article
- Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients.Intensive care medicine experimental · 2026Article
- Corticosteroids in severe community-acquired pneumonia: friend, foe or both?Pneumonia (Nathan Qld.) · 2026Review
- Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections.Open forum infectious diseases · 2026Article
- An immune-inflammatory dysregulation score for risk stratification of 28-day all-cause mortality in critically ill patients with severe community-acquired pneumonia.Frontiers in medicine · 2026Article
- Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies.EClinicalMedicine · 2025Article
- Evaluation of suPAR as a Key Prognostic Biomarker in Patients with SARS-CoV-2 Pneumonia.Biomedicines · 2025Article
- Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19.BMC infectious diseases · 2025Article
- Article
- The epidemiological characteristics of invasive pulmonary aspergillosis and risk factors for treatment failure: a retrospective study.BMC pulmonary medicine · 2024Article
- Lymphopenia in sepsis: a narrative review.Critical care (London, England) · 2024Review
- Development and validation of machine learning-based prediction model for severe pneumonia: A multicenter cohort study.Heliyon · 2024Article
- Predicting Organ Dysfunction in Septic and Critically Ill Patients: A Prospective Cohort Study Using Rapid Ex Vivo Immune Profiling.Critical care explorations · 2024Observational
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of neutrophil and lymphocyte counts in blood as prognosis predictors in Community Acquired Pneumonia (CAP) has not been adequately studied. This was a derivation-validation retrospective study in hospitalized patients with CAP and no prior immunosuppression. We evaluated by multivariate analysis the association between neutrophil and lymphocyte counts and mortality risk at 30-days post hospital admission in these patients. The derivation cohort (n=1550 patients) was recruited in a multi-site study. The validation cohort (n=2846 patients) was recruited in a single-site study. In the derivation cohort, a sub-group of lymphopenic patients, those with <724lymphocytes/mm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.