ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Factors associated with handgrip strength across the life course: A systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Efficacy of Digital Dance on Brain Imagery, Cognition, and Health: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Demographic factors associated with skin barrier function in a large population-based study.JID innovations : skin science from molecules to population health · 2026Article
- Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia.Nutrients · 2026Article
- Genetically Predicted Homocysteine Levels and B Vitamins on Sarcopenia-Related Traits: Insights From an Observational and Mendelian Randomization Analysis.Food science & nutrition · 2026Article
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- The association between multimorbidity and intrinsic capacity decline among older adults: the mediating role of frailty.BMC public health · 2025Article
- Review
- The unique presentation of the relationship between red blood cell folate and appendicular skeletal muscle mass: a cross-sectional study.Scientific reports · 2024Article
- Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.Aging medicine (Milton (N.S.W)) · 2024Article
- Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review.Nutrients · 2024Review
- Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018.Frontiers in nutrition · 2024Article
- Current approach to the diagnosis of sarcopenia in cardiovascular diseases.Frontiers in nutrition · 2024Review
- Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults.Frontiers in endocrinology · 2024Article
- Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023Review
- Relationship Between Plasma Homocysteine and Bone Density, Lean Mass, Muscle Strength and Physical Function in 1480 Middle-Aged and Older Adults: Data from NHANES.Calcified tissue international · 2023Article
- Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study.BMC geriatrics · 2022Article
- Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population.Scientific reports · 2022Article
- The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older People.Nutrients · 2022Article
- Association between Elevated Plasma Homocysteine and Low Skeletal Muscle Mass in Asymptomatic Adults.Endocrinology and metabolism (Seoul, Korea) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Decreased muscle strength is strongly associated with future mobility limitations in older adults. Homocysteine is a risk factor for vascular disease and may exacerbate muscle strength decline. The present study aimed to examine the association between homocysteine levels and muscle strength in adults aged 50 years or older. Methods: Data were from 1,101 participants of The Baltimore Longitudinal Study of Aging between December 2004 and March 2015. Muscle strength was measured using grip strength. Mixed effects linear regression was used to estimate the association between homocysteine and muscle strength in men and women, separately. Results: Total mean follow-up time was 4.7 ± 3.1 years, range from 0 to 10.1 years. Baseline mean grip strength was 39.9 kg for men and 25.5 kg for women. Grip strength declined over the follow-up time for both men and women. Among women, there was a significant inverse relationship between homocysteine and grip strength, where grip strength declined as a function of increasing homocysteine over time (β = -0.05, p = .031). Among men, an increase of 1 μmol/L in homocysteine was associated with -0.10 kg decrease in grip strength, though not significantly. Conclusions: In this study of healthy older adults aged 50 years or older, higher homocysteine was related to lower muscle strength in women. This is the first study to characterize the relationship over a long follow-up period. Future research should focus on assessing homocysteine as a marker of physical function decline and translating the relationship into clinical and public health practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.