ArticleSleep2017
Familial Risk for Insomnia Is Associated With Abnormal Cortisol Response to Stress.
Article in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Factors influencing insomnia among nurses in Wuhan, China, two years after the COVID-19 outbreak: a cross-sectional study.BMC nursing · 2026Article
- Sleep fragmentation after traumatic brain injury impairs behavior and conveys long-lasting impacts on neuroinflammation.Brain, behavior, & immunity - health · 2024Article
- DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis.Stem cell research & therapy · 2024Article
- Stress, hypothalamic pituitary adrenal axis activity and autonomic nervous system function in adolescents with insomnia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Hope Buffers the Effect of Fear of COVID-19 on Depression among College Students: Insomnia as a Mediator.International journal of environmental research and public health · 2023Article
- Stress dynamically reduces sleep depth: temporal proximity to the stressor is crucial.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injury.Experimental neurology · 2022Article
- Nightmare content during the COVID-19 pandemic: Influence of COVID-related stress and sleep disruption in the United States.Journal of sleep research · 2022Article
- Physiological responses to acute psychosocial stress in women with menopausal insomnia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
- Sleep Deprivation and Sleep-Onset Insomnia are Associated with Blunted Physiological Reactivity to Stressors.Military medicine · 2021Article
- A systematic review of the Trier Social Stress Test methodology: Issues in promoting study comparison and replicable research.Neurobiology of stress · 2020Review
- Factors associated with insomnia among Chinese front-line nurses fighting against COVID-19 in Wuhan: A cross-sectional survey.Journal of nursing management · 2020Article
- Association Between Childhood Behavioral Problems and Insomnia Symptoms in Adulthood.JAMA network open · 2019Article
- The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders.Journal of sleep research · 2018Review
- Hyperarousal and sleep reactivity in insomnia: current insights.Nature and science of sleep · 2018Review
- What do Cochrane systematic reviews say about interventions for insomnia?Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Objectives: Abnormalities in the stress system have been implicated in insomnia. However, studies examining physiological stress regulation in insomnia have not consistently detected differences in the hypothalamic-pituitary-adrenal (HPA)-axis response to stress. One explanation may be that deficits in the stress system are associated specifically with a biological vulnerability to insomnia rather than the phenotypic expression of insomnia. To examine stress response as a function of vulnerability to insomnia, this study tested response to the Trier Social Stress Test in a sample of healthy sleepers with varying familial risks for insomnia. Methods: Thirty-five healthy individuals with and without familial risk for insomnia were recruited to complete a laboratory stressor. Participants with one or both biological parents with insomnia were categorized as positive for familial risk, whereas those without biological parents with insomnia were categorized as negative for familial risk. Participants completed the Trier Social Stress Test in the laboratory, and psychological and physiological (autonomic and HPA-axis) responses were compared. Results: Despite self-reported increases in anxiety, those positive for familial risk exhibited a blunted cortisol response relative to those without familial risk for insomnia. Individuals with blunted cortisol also reported heightened reactivity to personal life stressors, including increased sleep disturbances, elevated cognitive intrusions, and more behavioral avoidance. Conclusions: Findings from this study provide initial evidence that abnormal stress regulation may be a biological predisposing factor conferred via familial risk for insomnia. This deficit may also predict negative consequences over time, including insomnia and the associated psychiatric comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.