ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 4 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.European geriatric medicine · 2026Pooled it
- Social determinants of multimorbidity patterns: A systematic review.Frontiers in public health · 2023Pooled it
- Barriers and facilitators for shared decision making in older patients with multiple chronic conditions: a systematic review.BMC geriatrics · 2021Pooled it
- Do replicable profiles of multimorbidity exist? Systematic review and synthesis.European journal of epidemiology · 2019Pooled it
- Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial.Nature aging · 2026Trial
- Promoting physical activity with self-management support for those with multimorbidity: a randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Trial
- Article
- Clinical Trials in Older Adults with Cardiovascular Multimorbidity: A Perspective on Pragmatic Trial Design.Journal of clinical medicine · 2026Article
- Frailty in middle adulthood and associations with negative health-related outcomes in NHANES.Aging clinical and experimental research · 2026Article
- Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study.BMC medicine · 2026Article
- Sex differences in the prevalence and cardiometabolic risk profiles of steatotic liver disease: A Canadian Longitudinal Study on Aging analysis.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Article
- Longitudinal Trajectories of Multimorbidity and Psychosocial Resilience Resources in Midlife and Older Adults: Findings From the Health and Retirement Study.Journal of aging and health · 2025Article
- The relationship between frailty and multimorbidity in Chinese older adults: the chain mediating effects of sleep quality and anxiety.BMC geriatrics · 2025Article
- Multimorbidity patterns and mortality in older adults: a two-cohort pooled analysis.Aging clinical and experimental research · 2025Article
- The Aging Lung: Exploring Multimorbidity Patterns and Their Clinical Implications: A Narrative Review.Current issues in molecular biology · 2025Review
- Association of dietary intake and whole blood essential trace elements with frailty in older adults: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Facilitators and barriers to medication self-management for patients with multiple long-term conditions transitioning from hospital to home.Exploratory research in clinical and social pharmacy · 2025Article
- Associations of Multimarkers of Metabolic Malnutrition and Inflammation with All-Cause Mortality by Multimorbidity Status.Nutrients · 2025Article
- Multimorbidity: Addressing the Elephant in the Clinic Room.Healthcare (Basel, Switzerland) · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs, and make people live more years of life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect of single conditions, as chronic diseases interact with each other, mutually enhancing their negative effects, and eventually leading to new clinical phenotypes. Moreover, multimorbidity mirrors an accelerated global susceptibility and a loss of resilience, which are both hallmarks of aging. Due to the complexity of its assessment and definition, and the lack of clear evidence steering its management, multimorbidity represents one of the main current challenges for clinicians, researchers, and policymakers. The authors of this article recently reflected on these issues during two twin international symposia at the 2016 European Union Geriatric Medicine Society (EUGMS) meeting in Lisbon, Portugal, and the 2016 Gerontological Society of America (GSA) meeting in New Orleans, USA. The present work summarizes the most relevant aspects related to multimorbidity, with the ultimate goal to identify knowledge gaps and suggest future directions to approach this condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.