ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Adiposity, Telomere Length, and Telomere Attrition in Midlife: the 1946 British Birth Cohort.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Telomere shortening associates with elevated insulin and nuchal fat accumulation.Scientific reports · 2020Trial
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- Relative Telomere Length and Cardiovascular Risk Factors.Biomolecules · 2019Article
- More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Background: Obesity has been linked with shorter telomere length, both of which have been implicated in ageing, but the impact of early life adiposity on telomere length is unclear. Methods: We included 2,479 participants from the MRC National Survey of Health and Development with measurements of body mass index, waist and hip circumference, and leukocyte telomere length (LTL) at age 53, of whom 1,000 had second measurements at ages 60-64. Relative LTL was measured with rt-PCR. Linear regression was performed to investigate associations between adiposity and LTL. Body mass index from childhood through adulthood was used to assess adiposity across the life course. Results: We found no cross-sectional associations between adiposity measures and LTL at ages 53 or 60-64. Longitudinally, each unit gain in waist circumference weakly corresponded with a 0.06% (95% CI: -1.31 to 0.10) LTL decrease annually, with association approaching statistical significance (p = 0.09). Being overweight at ages 6 and 15 corresponded to a nonsignificant shorter LTL at age 53 and they were associated with 2.06% (95% CI: 0.05-4.08%) and 4.26% (1.98-6.54%) less LTL attrition in midlife, respectively, compared to those who were not overweight. Conclusion: There is a weak indication that greater telomere loss was seen with greater concurrent body mass index gain. Adolescent overweight corresponded to shorter telomeres in midlife, albeit weakly, and with less subsequent attrition. Our findings point toward potential pathways which may link adiposity and ageing outcomes.
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