ArticleNeuroreport2017
Experimental rat model for cervical compressive myelopathy.
Article in Neuroreport, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Beyond the aging spine - a systematic review of functional changes in the human brain in cervical spondylotic myelopathy.GeroScience · 2024Pooled it
- The ferroptosis-mediated domino effect: metabolic crosstalk from intervertebral disc degeneration to spinal deformity and cord injury: a mini review.Frontiers in neuroscience · 2026Review
- Changes to Dorsal Thalamic Metabolites and Thalamocortical Tract Fiber Injury in Patients with Cervical Spondylotic Myelopathy.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Oligodendrogenic neural progenitors for treatment of chronic compressive cervical spinal cord injury.Stem cells translational medicine · 2025Article
- A preclinical study on cell therapy as an adjunct to surgical decompression in degenerative cervical myelopathy via accelerating blood spinal cord barrier reconstitution and neurological recovery.Stem cell research & therapy · 2025Article
- Differences in the expression of myelopathy in a rat model of chronic spinal cord compression.The journal of spinal cord medicine · 2024Article
- Blood-spinal cord barrier disruption in degenerative cervical myelopathy.Fluids and barriers of the CNS · 2023Review
- Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events.Neural regeneration research · 2023Article
- Impaired communication at the neuromotor axis during Degenerative Cervical Myelopathy.Frontiers in cellular neuroscience · 2023Article
- Spinal Canal and Spinal Cord in Rat Continue to Grow Even after Sexual Maturation: Anatomical Study and Molecular Proposition.International journal of molecular sciences · 2022Article
- Animal models of compression spinal cord injury.Journal of neuroscience research · 2022Review
- Early decompression promotes motor recovery after cervical spinal cord injury in rats with chronic cervical spinal cord compression.Scientific reports · 2022Article
- Different responses of cervical intervertebral disc caused by low and high virulence bacterial infection: a comparative study in rats.Bioengineered · 2022Article
- A sheep model of chronic cervical compressive myelopathy via an implantable wireless compression device.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Article
- Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model.Scientific reports · 2020Article
- MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression.European radiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, a rat model of chronic compressive myelopathy that uses a water-absorbing polymer inserted under a spinal lamina was reported. However, the best size and coefficient of expansion of the polymer sheet have not yet been established. The aim of the present study was to optimize these properties in an ideal rat model of cervical compressive myelopathy. Thirty rats were used in this study. A sheet of water-absorbing polymer was inserted under the cervical laminae. Rats were divided randomly into five experimental groups by the expansion rate (350 or 200%) and thickness (0.5 or 0.7 mm) and the control. After the surgery, the severity of paralysis was evaluated for 12 weeks. At 12 weeks after the surgery, cresyl violet staining was performed to assess the number of motor neurons in the anterior horn at the C4/C5 segment and Luxol Fast Blue staining was performed to assess demyelination in the corticospinal tract at the C7 segment. 'Slow-progressive' paralysis appeared at 4-8 weeks postoperatively in rat models using sheets with 200% expansion. By contrast, only temporary paralysis was observed in rat models using sheets with 350% expansion. A loss of motor neurons in the anterior horn was observed in all groups, except for the control. Demyelination in the corticospinal tract was observed in rat models using sheets with 200% expansion, but not rat models using sheets with 350% expansion. A polymer sheet that expands its volume by 200% is an ideal material for rat models of cervical compressive myelopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.