Evidence map›Paper›PMID 28957729›Full record

ReviewCurrent opinion in neurobiology2017

Livin' On The Edge: glia shape nervous system transition zones.

Laura Fontenas, Sarah Kucenas

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Investigating Primary Cilia during Peripheral Nervous System Formation.International journal of molecular sciences · 2021
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura FontenasDepartment of Biology, University of Virginia, Charlottesville, VA 22904, United States.
Sarah KucenasDepartment of Biology, University of Virginia, Charlottesville, VA 22904, United States. Electronic address: sk4ub@virginia.edu.

Funding

Genetic Analysis of Glial Contribution to Peripheral Nervous System AssemblyR01NS072212 · NINDS · UNIVERSITY OF VIRGINIA · PI KUCENAS, SARAH C · 2010 to 2019
$3.5M
Investigating Glial Interactions Across the Motor Exit Point During DevelopmentR21NS092070 · NINDS · UNIVERSITY OF VIRGINIA · PI KUCENAS, SARAH C · 2015 to 2016
$426k
NINDS NIH HHS R01 NS072212NINDS NIH HHS R21 NS092070
6 · The paper itself

Abstract

The vertebrate nervous system is divided into two functional halves; the central nervous system (CNS), which includes the brain and spinal cord, and the peripheral nervous system (PNS), which consists of nerves and ganglia. Incoming peripheral stimuli transmitted from the periphery to the CNS and subsequent motor responses created because of this information, require efficient communication between the two halves that make up this organ system. Neurons and glial cells of each half of the nervous system, which are the main actors in this communication, segregate across nervous system transition zones and never mix, allowing for efficient neurotransmission. Studies aimed at understanding the cellular and molecular mechanisms governing the development and maintenance of these transition zones have predominantly focused on mammalian models. However, zebrafish has emerged as a powerful model organism to study these structures and has allowed researchers to identify novel glial cells and mechanisms essential for nervous system assembly. This review will highlight recent advances into the important role that glial cells play in building and maintaining the nervous system and its boundaries.

Indexed as

AnimalsCentral Nervous SystemHumansNeurogliaNeuronsPeripheral Nervous SystemSynaptic TransmissionZebrafish

Identifiers

PMID28957729
PMCPMC5732850

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.