ArticleNeuron2017
Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.
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Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 98 citations in OpenAlex.
- β-Arrestin-2 Regulates Sodium Taste Processing.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- Rapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite.bioRxiv : the preprint server for biology · 2026Article
- Tetrodotoxin-resistant NaMolecular psychiatry · 2026Article
- Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus.The Journal of comparative neurology · 2026Article
- Modulation of attractive salt taste iniScience · 2026Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Cell reports · 2026Article
- AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Research square · 2025Article
- Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected.Pflugers Archiv : European journal of physiology · 2025Article
- High salt intake exacerbates aldosterone-related target organ damage in patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- What's the occasion? Phasic dopamine signaling and interoception.Current opinion in neurobiology · 2025Review
- Targeted cravings: Unraveling the drivers of nutrient-specific appetite.Current opinion in neurobiology · 2025Review
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Aldosterone-induced salt appetite requires HSD2 neurons.JCI insight · 2024Article
- Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024Article
- Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels.Science (New York, N.Y.) · 2024Article
- Dorsal raphe dopaminergic neurons target CaMKIITranslational psychiatry · 2024Article
- Control of sodium appetite by hindbrain aldosterone-sensitive neurons.Molecular and cellular endocrinology · 2024Review
- Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure.Physiological reports · 2024Review
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Authors and funding
16 authors at 3 institutions in 1 country.
Jon M ReschDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Henning FenselauDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Joseph C MadaraDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Chen WuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
John N CampbellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Anna LyubetskayaDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Brian A DawesDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Linus T TsaiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Monica M LiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Yoav LivnehDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Qingen KeCardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Peter M KangCardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Géza Fejes-TóthDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03755, USA.
Anikó Náray-Fejes-TóthDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03755, USA.
Joel C GeerlingDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: joel-geerling@uiowa.edu.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: blowell@bidmc.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USDartmouth College · US
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MNeurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0MGlutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of SatietyR01DK111401 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2016 to 2020
$2.2MPB-FI connectivity and arousalK08NS099425 · NINDS · UNIVERSITY OF IOWA · PI GEERLING, JOEL CHARLES · 2017 to 2021
$961kThe Role of TGF-beta in the pathogenesis of Experimental Biliary AtresiaK08DK083769 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NADLER, EVAN P · 2008 to 2012
$741kAgRP neurocircuitry regulating energy expenditureF32DK103387 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RESCH, JON · 2014 to 2017
$159kNIDDK NIH HHS F32 DK103387NIDDK NIH HHS K08 DK083769NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401NINDS NIH HHS K08 NS099425
Abstract
Sodium deficiency increases angiotensin II (ATII) and aldosterone, which synergistically stimulate sodium retention and consumption. Recently, ATII-responsive neurons in the subfornical organ (SFO) and aldosterone-sensitive neurons in the nucleus of the solitary tract (NTS
Indexed as
Signal TransductionAldosteroneAngiotensin IIAnimalsBiological ClocksEatingHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMiceMice, TransgenicNAV1.5 Voltage-Gated Sodium ChannelNeural PathwaysNeuronsSeptal NucleiSodiumSolitary NucleusAldosteroneAngiotensin IIHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSodium11β-Hydroxysteroid dehydrogenase 2aldosteroneangiotensin IIbed nucleus of the stria terminaliselectrophysiologyHCN channelsNa(v)1.5nucleus of the solitary tractpacemaker activitysodium appetite
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