ArticleMolecular biology and evolution2017
Inferring Past Environments from Ancient Epigenomes.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- The epigenetic archaeology of human-dog companionship.Epigenetics · 2026Review
- Naturally-occurring DNA fragment termini correlate with methylation at CpG sites in hair and blood plasma cell-free DNA.BMC genomics · 2026Article
- RoAM: computational reconstruction of ancient methylomes and identification of differentially methylated regions.Genome biology · 2025Article
- Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples.Biological procedures online · 2025Article
- Improved detection of methylation in ancient DNA.Genome biology · 2024Article
- Reconstructing DNA methylation maps of ancient populations.Nucleic acids research · 2024Article
- Evolution of Homo in the Middle and Late Pleistocene.Journal of human evolution · 2022Review
- Review
- Differential DNA methylation of vocal and facial anatomy genes in modern humans.Nature communications · 2020Article
- The 4 D's of Pellagra and Progress.International journal of tryptophan research : IJTR · 2020Review
- Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits.Genome biology and evolution · 2019Article
- Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?International journal of tryptophan research : IJTR · 2019Review
- Recently evolved human-specific methylated regions are enriched in schizophrenia signals.BMC evolutionary biology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analyzing the conditions in which past individuals lived is key to understanding the environments and cultural transitions to which humans had to adapt. Here, we suggest a methodology to probe into past environments, using reconstructed premortem DNA methylation maps of ancient individuals. We review a large body of research showing that differential DNA methylation is associated with changes in various external and internal factors, and propose that loci whose DNA methylation level is environmentally responsive could serve as markers to infer about ancient daily life, diseases, nutrition, exposure to toxins, and more. We demonstrate this approach by showing that hunger-related DNA methylation changes are found in ancient hunter-gatherers. The strategy we present here opens a window to reconstruct previously inaccessible aspects of the lives of past individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.