ArticleMolecular biology and evolution2017
Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Multiscale structural evolution of proline-rich protein genes shapes primate salivary defenses.Molecular biology and evolution · 2026Article
- TheScience (New York, N.Y.) · 2025Article
- Deciphering the role of structural variation in human evolution: a functional perspective.Current opinion in genetics & development · 2024Review
- Emergence of saliva protein genes in the secretory calcium-binding phosphoprotein (SCPP) locus and accelerated evolution in primates.bioRxiv : the preprint server for biology · 2024Article
- A Catalog of Coding Sequence Variations in Salivary Proteins' Genes Occurring during Recent Human Evolution.International journal of molecular sciences · 2023Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Review
- MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations.Molecular biology and evolution · 2023Article
- sstar: A Python Package for Detecting Archaic Introgression from Population Genetic Data with S.Molecular biology and evolution · 2022Article
- Including diverse and admixed populations in genetic epidemiology research.Genetic epidemiology · 2022Article
- The history and evolution of the Denisovan-Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- African genetic diversity and adaptation inform a precision medicine agenda.Nature reviews. Genetics · 2021Review
- Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.Cell reports · 2020Article
- VolcanoFinder: Genomic scans for adaptive introgression.PLoS genetics · 2020Article
- Article
- Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome.Molecular biology and evolution · 2020Article
- Recovering signals of ghost archaic introgression in African populations.Science advances · 2020Article
- An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health.Journal of molecular evolution · 2020Review
- Genomics of disease risk in globally diverse populations.Nature reviews. Genetics · 2019Review
- Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations.Genome biology · 2019Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying five or six PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeats and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans.
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