Evidence map›Paper›PMID 28957449›Full record

ReviewPLoS pathogens2017

Plasmodium heme biosynthesis: To be or not to be essential?

Daniel E Goldberg, Paul A Sigala

Abstract readReview
In one paragraph

Review in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. A Divergent CytochromebioRxiv : the preprint server for biology · 2025
    Article
  5. Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025
    Review
  6. Biogenesis of CytochromesACS infectious diseases · 2025
    Article
  7. Article
  8. Review
  9. Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Biogenesis of cytochromesbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Direct tests of cytochromeProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Chemical research in toxicology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Reactive Oxygen Species as the Brainbox in Malaria Treatment.Antioxidants (Basel, Switzerland) · 2021
    Review
  20. Microbiology (Reading, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0003-3529-8399
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.ORCID 0000-0002-3464-3042

Funding

Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
ROLE OF PFHO-1 IN P. FALCIPARUM INTRAERYTHROCYTIC DEVELOPMENTR21AI110712 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2015
$408k
NIAID NIH HHS R21 AI110712NIAID NIH HHS T32 AI007172NIDDK NIH HHS U54 DK110858NIH HHS AI110712
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsHemeHost-Parasite InteractionsHumansMalariaPlasmodium falciparumHeme

Identifiers

PMID28957449
PMCPMC5619821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.