ArticlePloS one2017
Clinical characteristics and survival of lung cancer patients associated with multiple primary malignancies.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Prevalence of lung tumors in patients with esophageal squamous cell carcinoma and vice versa: a systematic review and meta-analysis.Journal of cancer research and clinical oncology · 2023Pooled it
- A case report: Achieving complete response in synchronous primary lung and tongue squamous cell carcinomas through the integration of albumin-bound paclitaxel, cisplatin, and tislelizumab.Human vaccines & immunotherapeutics · 2025Article
- Clinical features and prognostic nomogram development for cancer-specific death in patients with dual primary lung cancer: a population-based study from SEER database.Journal of cardiothoracic surgery · 2025Article
- Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer.Cancer medicine · 2024Article
- Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities.Cancer cell international · 2024Article
- Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid: A case report.World journal of clinical cases · 2023Article
- Surgical selection and regional lymph node dissection for stage I second primary lung cancer patients following surgery for stage I first primary lung cancer.Frontiers in oncology · 2023Article
- Association between radiotherapy for surgically treated oral cavity cancer and secondary lung cancer.Frontiers in public health · 2023Article
- Survival Analysis in Patients with Lung Cancer and Subsequent Primary Cancer: A Nationwide Cancer Registry Study.Journal of clinical medicine · 2022Article
- Multiple primary malignancies - hepatocellular carcinoma combined with splenic lymphoma: A case report.World journal of clinical cases · 2022Article
- Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report.Open medicine (Warsaw, Poland) · 2022Article
- Clinical features and survival of patients with multiple primary malignancies.World journal of clinical cases · 2021Article
- Mutational status of main driver genes influences the prognosis of stage I-III lung adenocarcinoma patients underwent radical surgery.Translational cancer research · 2021Article
- [Analysis of Clinical Characteristics of Lung Cancer Combined with Multiple Primary Malignancies in Other Organs].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021Article
- Previous Extrapulmonary Malignancies Impact Outcomes in Patients With Surgically Resected Lung Cancer.Frontiers in surgery · 2021Article
- Spectrum ofArchives of medical science : AMS · 2020Article
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- The Characteristic of Secondary Lung Tumours in Medan.Open access Macedonian journal of medical sciences · 2019Article
- Lung cancer patients with a previous extra-pulmonary malignancy should not be considered homogeneous: a clinicopathological analysis of 3530 surgical cases.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the characteristics and survival of lung cancer patients with additional malignant primary cancers.
methodsRecords of lung cancer patients newly diagnosed in Shanghai Pulmonary Hospital between January 2000 and January 2010 were retrospectively reviewed. Patients with second primary lung cancer and those with lung cancer only were included for detailed analysis.
resultsOf 27642 newly diagnosed lung cancer patients, 283 patients (1.02%) suffered previous additional primary cancers. Compared with single primary lung cancer, patients with secondary lung cancer associated other primary cancers were more often women (female to male ratio 1:1.72 vs 1:2.58, P = 0.018), older (64.2 vs 60.5 years old, P<0.001), more squamous cell type (30.7% vs 20.5%, P = 0.004), less small cell (3.9% vs 15.5%, P<0.001) type, at earlier stages (17.7% vs 11.0% for stage I, P = 0.014), and more frequently with family history of cancers (7.8% vs 3.9%, P = 0.038). The most common previous primary cancers observed were colorectal (22.0%), breast (18.4%), gastric (14.4%) and larynx cancers (11.9%). Approximately 42.9% of patients were diagnosed with lung cancer 2 to 6 years after diagnosis of initial primary cancers. The survival of patients with secondary lung cancer associated other malignancies was not significantly different from those with single lung cancer (P = 0.491), while synchronous multiple primary malignancies showed worse prognosis compared with those with metachronous ones or single lung cancer (p = 0.012).
conclusionThe possibility of second primary lung cancer should always be considered during the follow-up of related cancer types, especially those with family history of cancers. Patients with secondary lung cancer associated other primary malignancies have non-inferior survival than those with single lung cancer.
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