ArticleBehavioral neuroscience2017
Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses.
Article in Behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Increased CSF volume, altered brain development and emotional reactivity after postnatal Zika virus infection in infant rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Impaired Cognitive Flexibility After Neonatal Perirhinal Lesions in Rhesus Macaques.Frontiers in systems neuroscience · 2019Article
- Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques.Developmental cognitive neuroscience · 2017Article
- Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses.Behavioral neuroscience · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The medial temporal lobe (MTL) is a collection of brain regions best known for their role in perception, memory, and emotional behavior. Within the MTL, the perirhinal cortex (PRh) plays a critical role in perceptual representation and recognition memory, although its contribution to emotional regulation is still debated. Here, rhesus monkeys with neonatal perirhinal lesions (Neo-PRh) and controls (Neo-C) were tested on the Human Intruder (HI) task at 2 months, 4.5 months, and 5 years of age to assess the role of the PRh in the development of emotional behaviors. The HI task presents a tiered social threat to which typically developing animals modulate their emotional responses according to the level of threat. Unlike animals with neonatal amygdala or hippocampal lesions, Neo-PRh animals were not broadly hyper- or hyporesponsive to the threat presented by the HI task as compared with controls. Instead, Neo-PRh animals displayed an impaired ability to modulate their freezing and anxiety-like behavioral responses according to the varying levels of threat. Impaired transmission of perceptual representation generated by the PRh to the amygdala and hippocampus may explain the animals' inability to appropriately assess and react to complex social stimuli. Neo-PRh animals also displayed fewer hostile behaviors in infancy and more coo vocalizations in adulthood. Neither stress-reactive nor basal cortisol levels were affected by the Neo-PRh lesions. Overall, these results suggest that the PRh is indirectly involved in the expression of emotional behavior and that effects of Neo-PRh lesions are dissociable from neonatal lesions to other temporal lobe structures. (PsycINFO Database Record
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