ArticleViruses2017
Comment: Characterization of Two Historic Smallpox Specimens from a Czech Museum.
Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Smallpox in Greece: A Narrative Review.Cureus · 2025Review
- Exploiting Viral DNA Genomes to Explore the Dispersal History of African Swine Fever Genotype II Lineages in Europe.Genome biology and evolution · 2025Article
- Molecular epidemiology of recurrent zoonotic transmission of mpox virus in West Africa.medRxiv : the preprint server for health sciences · 2024Article
- Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records.Microbial genomics · 2023Article
- Review
- An Update of Orthopoxvirus Molecular Evolution.Viruses · 2022Article
- Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018.Scientific reports · 2021Article
- Variola virus genome sequenced from an eighteenth-century museum specimen supports the recent origin of smallpox.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity.Nature microbiology · 2020Article
- Bayesian Phylogeography and Pathogenic Characterization of Smallpox Based on HA, ATI, and CrmB Genes.Molecular biology and evolution · 2018Article
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4 authors.
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Abstract
The complete genome sequences of two strains of variola virus (VARV) sampled from human smallpox specimens present in the Czech National Museum, Prague, were recently determined, with one of the sequences estimated to date to the mid-19th century. Using molecular clock methods, the authors of this study go on to infer that the currently available strains of VARV share an older common ancestor, at around 1350 AD, than some recent estimates based on other archival human samples. Herein, we show that the two Czech strains exhibit anomalous branch lengths given their proposed age, and by assuming a constant rate of evolutionary change across the rest of the VARV phylogeny estimate that their true age in fact lies between 1918 and 1937. We therefore suggest that the age of the common ancestor of currently available VARV genomes most likely dates to late 16th and early 17th centuries and not ~1350 AD.
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