ArticleJournal of virology2017
The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.
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Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 41 citations in OpenAlex.
- Herpes simplex virus 1 subverts the mitochondrial network to support the infection: A lesson on mitochondrial versatility.bioRxiv : the preprint server for biology · 2026Article
- Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity.PLoS pathogens · 2026Article
- The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity.bioRxiv : the preprint server for biology · 2026Article
- Herpes simplex virus alkaline nuclease interacts directly with ubiquitin-specific protease 15 through a conserved C-terminal domain.The Journal of biological chemistry · 2026Article
- The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition.The Journal of biological chemistry · 2026Article
- Partial inhibition of viral replication machinery enhances recombination in herpes simplex viruses.Biology direct · 2025Article
- Discovery of a Baloxavir-Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stability.Journal of virology · 2025Article
- The herpes simplex virus alkaline nuclease is required to maintain replication fork progression.Journal of virology · 2024Article
- Control of HSV-1 Infection: Directions for the Development of CRISPR/Cas-Based Therapeutics and Diagnostics.International journal of molecular sciences · 2024Review
- Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms.Cell reports · 2024Article
- Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires.Nature communications · 2024Article
- Summary of the Centers for Disease Control and Prevention/National Institute of Allergy and Infectious Diseases Joint Workshop on Genital Herpes: 3-4 November 2022.Open forum infectious diseases · 2024Review
- DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage.Cell systems · 2024Article
- Screening and identification of emodin as an EBV DNase inhibitor to prevent its biological functions.Virology journal · 2023Article
- Antiviral activity of amide-appended α-hydroxytropolones against herpes simplex virus-1 and -2.RSC advances · 2023Article
- DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production.Nucleic acids research · 2023Article
- Regulation of alphaherpesvirus protein via post-translational phosphorylation.Veterinary research · 2022Review
- Host translesion polymerases are required for viral genome integrity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Lorry M GradyDepartment of Molecular Biology and Biophysics and the Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Renata SzczepaniakDepartment of Molecular Biology and Biophysics and the Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Ryan P MurelliDepartment of Chemistry, Brooklyn College, City University of New York, Brooklyn, New York, USA.
Takeshi MasaokaBasic Research Laboratory, National Cancer Institute, Frederick, Maryland, USA.
Stuart F J Le GriceBasic Research Laboratory, National Cancer Institute, Frederick, Maryland, USA.
Dennis L WrightDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.
Sandra K WellerDepartment of Molecular Biology and Biophysics and the Molecular Biology and Biochemistry Graduate Program, University of Connecticut School of Medicine, Farmington, Connecticut, USA weller@uchc.edu.
University of Connecticut · USCity University of New York · USFrederick National Laboratory for Cancer Research · USNational Cancer Institute · US
Funding
GENETICS OF HSV DNA REPLICATIONR01AI021747 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WELLER, SANDRA K, WRIGHT, DENNIS L. · 1985 to 2024
$9.9MViral and Host Proteins as Therapeutic TargetsZIABC010494 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LE GRICE, STUART F. J. · 2009 to 2021
$9.0MGENETICS OF HSV DNA REPLICATIONR37AI021747 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WELLER, SANDRA K · 1998 to 2007
$3.3MRole of viral and cellular recombination proteins in HSV DNA replicationR01AI069136 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WELLER, SANDRA K · 2006 to 2016
$3.1MDevelopment and Exploitation of New Synthetic Strategies for TropolonesSC1GM111158 · NIGMS · BROOKLYN COLLEGE · PI MURELLI, RYAN · 2015 to 2023
$3.1MHDAC Inhibitors Inspired by Natural ProductsR21CA162470 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI WRIGHT, DENNIS L. · 2011 to 2012
$361kNCI NIH HHS R21 CA162470NIAID NIH HHS R01 AI021747NIAID NIH HHS R01 AI069136NIAID NIH HHS R37 AI021747NIGMS NIH HHS SC1 GM111158
Abstract
The herpes simplex virus (HSV) type I alkaline nuclease, UL12, has 5'-to-3' exonuclease activity and shares homology with nucleases from other members of the
Indexed as
MutationVirus AssemblyAnimalsCapsidChlorocebus aethiopsDeoxyribonucleasesDNA ReplicationHerpesvirus 1, HumanHumansVero CellsViral ProteinsVirus ReplicationDeoxyribonucleasesUL12 protein, herpes simplex virus 1Viral ProteinsDNA recombinationDNA replicationdrug discoveryexonucleasesHSVUL12viral DNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.