Evidence map›Paper›PMID 28956756›Full record

ArticleRNA (New York, N.Y.)2017

Kelly A Limoncelli, Christopher N Merrikh, Melissa J Moore

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Article
  9. Article
  10. Detecting and Rescuing Stalled Ribosomes.Trends in biochemical sciences · 2021
    Review
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  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kelly A LimoncelliDepartment of Biochemistry and Molecular Pharmacology, RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Christopher N MerrikhDepartment of Biochemistry and Molecular Pharmacology, RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Melissa J MooreDepartment of Biochemistry and Molecular Pharmacology, RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
University of Massachusetts Chan Medical School · US

Funding

Investigating the functional roles of RPS3 in RNA and DNA damageF31GM109753 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIMONCELLI, KELLY ANN · 2014 to 2017
$117k
NIGMS NIH HHS F31 GM109753
6 · The paper itself

Abstract

In budding yeast, inactivating mutations within the 40S ribosomal subunit decoding center lead to 18S rRNA clearance by a quality control mechanism known as nonfunctional 18S rRNA decay (18S NRD). We previously showed that 18S NRD is functionally related to No-Go mRNA Decay (NGD), a pathway for clearing translation complexes stalled on aberrant mRNAs. Whereas the NGD factors Dom34p and Hbs1p contribute to 18S NRD, their genetic deletion (either singly or in combination) only partially stabilizes mutant 18S rRNA. Here we identify Asc1p (aka RACK1) and Rps3p, both stable 40S subunit components, as additional 18S NRD factors. Complete stabilization of mutant 18S rRNA in

Indexed as

Protein Processing, Post-TranslationalRNA StabilityAdaptor Proteins, Signal TransducingGTP-Binding ProteinsRibosomal ProteinsRNA, FungalRNA, Ribosomal, 18SSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdaptor Proteins, Signal TransducingASC1 protein, S cerevisiaeGTP-Binding ProteinsRibosomal ProteinsRNA, FungalRNA, Ribosomal, 18SRPS3 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsribosomeRNA decayRNA quality controlRPS3translation

Identifiers

PMID28956756
PMCPMC5689013
OpenAlexW2757536737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.