Evidence map›Paper›PMID 28956734›Full record

Trial reportRadiology2018

Coronary Artery Disease: Analysis of Diagnostic Performance of CT Perfusion and MR Perfusion Imaging in Comparison with Quantitative Coronary Angiography and SPECT-Multicenter Prospective Trial.

Matthias Rief, Marcus Y Chen, Andrea L Vavere, Benjamin Kendziora, Julie M Miller, W Patricia Bandettini, Christopher Cox, Richard T George, João Lima, Marcelo Di Carli and 6 more

Open access · greenAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Spectrum of clinical applications of interlead ECG heterogeneity assessment: From myocardial ischemia detection to sudden cardiac death risk stratification.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021
    Review
  6. Cardiac CT perfusion and FFRCardiovascular diagnosis and therapy · 2020
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Myocardial Perfusion Imaging: A Brief Review of Nuclear and Nonnuclear Techniques and Comparative Evaluation of Recent Advances.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Matthias RiefFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Marcus Y ChenFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Andrea L VavereFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Benjamin KendzioraFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Julie M MillerFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
W Patricia BandettiniFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Christopher CoxFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Richard T GeorgeFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
João LimaFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Marcelo Di CarliFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Michail PlotkinFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Elke ZimmermannFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Michael LauleFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Peter SchlattmannFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Andrew E AraiFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Marc DeweyFrom the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).
Johns Hopkins University · US

Funding

Technical Development of Diagnostic Cardiovascular MRIZIAHL004607 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2009 to 2020
$25.3M
Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
Quantification of Myocardial PerfusionZIAHL006137 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2011 to 2020
$9.4M
6 · The paper itself

Abstract

Purpose To compare the diagnostic performance of stress myocardial computed tomography (CT) perfusion with that of stress myocardial magnetic resonance (MR) perfusion imaging in the detection of coronary artery disease (CAD). Materials and Methods All patients gave written informed consent prior to inclusion in this institutional review board-approved study. This two-center substudy of the prospective Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) multicenter trial included 92 patients (mean age, 63.1 years ± 8.1 [standard deviation]; 73% male). All patients underwent perfusion CT and perfusion MR imaging with either adenosine or regadenoson stress. The predefined reference standards were combined quantitative coronary angiography (QCA) and single-photon emission CT (SPECT) or QCA alone. Results from coronary CT angiography were not included, and diagnostic performance was evaluated with the Mantel-Haenszel test stratified by disease status. Results The prevalence of CAD was 39% (36 of 92) according to QCA and SPECT and 64% (59 of 92) according to QCA alone. When compared with QCA and SPECT, per-patient diagnostic accuracy of perfusion CT and perfusion MR imaging was 63% (58 of 92) and 75% (69 of 92), respectively (P = .11); sensitivity was 92% (33 of 36) and 83% (30 of 36), respectively (P = .45); and specificity was 45% (25 of 56) and 70% (39 of 56), respectively (P < .01). When compared with QCA alone, diagnostic accuracy of CT perfusion and MR perfusion imaging was 82% (75 of 92) and 74% (68 of 92), respectively (P = .27); sensitivity was 90% (53 of 59) and 69% (41 of 59), respectively (P < .01); and specificity was 67% (22 of 33) and 82% (27 of 33), respectively (P = .27). Conclusion This multicenter study shows that the diagnostic performance of perfusion CT is similar to that of perfusion MR imaging in the detection of CAD.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMultidetector Computed TomographyMultimodal ImagingMyocardial Perfusion ImagingProspective StudiesTomography, Emission-Computed, Single-Photon

Identifiers

PMID28956734
PMCPMC5790301
OpenAlexW2760203899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.