Evidence map›Paper›PMID 28956656›Full record

ArticleCurrent eye research2018

A method for volumetric retinal tissue oxygen tension imaging.

Anthony E Felder, Justin Wanek, Pang-Yu Teng, Norman P Blair, Mahnaz Shahidi

Abstract read
In one paragraph

Article in Current eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026
    Article
  2. Review
  3. In vivo OScientific reports · 2020
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anthony E Feldera Department of Bioengineering , University of Illinois at Chicago , Chicago IL, USA.
Justin Wanekb Department of Ophthalmology and Visual Science , University of Illinois at Chicago , Chicago IL, USA.
Pang-Yu Tengb Department of Ophthalmology and Visual Science , University of Illinois at Chicago , Chicago IL, USA.
Norman P Blairb Department of Ophthalmology and Visual Science , University of Illinois at Chicago , Chicago IL, USA.
Mahnaz Shahidic Department of Ophthalmology , University of Southern California , Los Angeles CA, USA.

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Noninvasive Imaging of Chorioretinal Oxygen TensionR01EY017918 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2007 to 2022
$6.2M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY017918
6 · The paper itself

Abstract

purposeInadequate retinal oxygenation occurs in many vision-threatening retinal diseases, including diabetic retinopathy, retinal vascular occlusions, and age-related macular degeneration. Therefore, techniques that assess retinal oxygenation are necessary to understand retinal physiology in health and disease. The purpose of the current study is to report a method for the three-dimensional (3D) imaging of retinal tissue oxygen tension (tPO

methodsImaging was performed in Long Evans pigmented rats under systemic normoxia (N = 6) or hypoxia (N = 3). A vertical laser line was horizontally scanned on the retina and a series of optical section phase-delayed phosphorescence images were acquired. From these images, phosphorescence volumes at each phase delay were constructed and a 3D retinal tPO

resultsEach 3D retinal tPO

conclusionFor the first time, 3D imaging of retinal tPO

Indexed as

AnimalsDisease Models, AnimalHypoxiaImaging, Three-DimensionalOxygenOxygen ConsumptionRatsRats, Long-EvansRetinaRetinal DiseasesOxygenphosphorescence lifetime imagingRatretinathree-dimensional imagingtissue oxygen tension

Identifiers

PMID28956656
PMCPMC6037488

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.